Results 41 to 50 of about 25,175,905 (236)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Efficient waste heat utilization in high-temperature proton exchange membrane fuel cell bus through integration of lithium bromide absorption refrigeration

Heliyon
Compression-type air-conditioning heat pump systems used in high-temperature proton exchange membrane fuel cell (HT-PEMFC) buses significantly increase the vehicle's hydrogen consumption.
Ke Song, Zhen Cai, Xing Huang, Haoran Ma, Yanju Li, Pengyu Huang, Boqiang Zhang   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stationary Fuel Cell System Composite Data Products: Data Through Quarter 4 of 2012 [PDF]

, 2013
This presentation from the U.S. Department of Energy's National Renewable Energy Laboratory includes stationary fuel cell system composite data products for data through the fourth quarter of ...
Saur, G., Ainscough, C., Kurtz, J.
core   +1 more source

Experimental Comparison of Three Real-Time Optimization Strategies Applied to Renewable/FC-Based Hybrid Power Systems Based on Load-Following Control

Energies, 2018
Besides three different real-time optimization strategies analyzed for the Renewable/Fuel Cell Hybrid Power Systems (REW/FC-HPS) based on load-following (LFW) control, a short but critical assessment of the Real-Time Optimization (RTO) strategies is ...
Nicu Bizon, Mihai Oproescu
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A case study analysis of system efficiency, viability and energy values of SOFC based fuel cell Micro-CHP for office buildings [PDF]

, 2015
The built environment is a large contributor to the greenhouse gas emissions. The first step in tackling environmental impact and fuel cost reduction is the minimization of energy losses through introduction of new and more efficient energy conversion ...
Mylona, A., Irvine, John Thomas Sirr, Connor, Paul Alexander, Cassidy, Mark, Tesfai, Alem, Connor, Paul Alexander; id_orcid, Irvine, John Thomas Sirr; id_orcid   +6 more
core   +1 more source

Coordinated Control of Fuel Cell Hybrid Power System for Trams Based on DP Optimization

机车电传动, 2021
In order to reduce the hydrogen consumption of the fuel cell/lithium battery hybrid power system for trams, improve the rate of change of fuel cell power, and avoid the accumulation of lithium battery state of charge (SOC) power shortage or excess power ...
Lei XU, Qing TIAN, Yankun LI
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source