Results 121 to 130 of about 10,509 (217)

Ketogenic Diet and β‐Hydroxybutyrate Suppress Bladder Cancer Growth and Enhance Anti‐PD‐L1 Immunotherapy Efficacy

Cancer Science, EarlyView.
Ketogenic diet and β‐hydroxybutyrate (β‐HB) suppress bladder cancer growth through direct anti‐tumor mechanisms and enhance anti‐PD‐L1 immunotherapy efficacy. β‐HB upregulates PD‐L1 via JAK2‐STAT3 activation and remodels the tumor immune microenvironment, sensitizing tumors to immune checkpoint blockade. ABSTRACT The limited clinical efficacy of immune
Yuan Zeng, Gangli Gu, Lin Yang, Bohao Fan, Haochen Cui, Lei Yan, Zhao Liu   +6 more
wiley   +1 more source

An analytical approach to generating orbital maneuver sets for spacecraft on-orbit services. [PDF]

Sci Rep
Xue J, Zhao S, Yang M, Jiang Y, Zhang Y, Tao X.   +5 more
europepmc   +1 more source

Effects of restoration practices on biodiversity in temperate and boreal forests

Conservation Biology, EarlyView.
Abstract Several restoration practices are used to mitigate and compensate for the negative effects of large‐scale forestry on biodiversity in temperate and boreal forests. A comprehensive synthesis of the benefits of these practices across taxa is missing. We conducted a systematic review and meta‐analysis on this topic.
Malin Tälle, Thomas Ranius, Julia Koricheva   +2 more
wiley   +1 more source

Synchrotron radiation analysis of microparticles from the Fukushima Daiichi nuclear power station. [PDF]

Commun Chem
Kobayashi T, Kobata M, Tanida H, Okamoto Y, Fujimori SI, Takeda Y, Tsuji T, Fukuda T, Shibata G, Kawasaki I, Doi R, Okane T, Satou Y, Suzuki S, Maeda K, Yaita T.   +15 more
europepmc   +1 more source

Marine plastic pollution undermines the livelihoods and income of fishing communities in Viet Nam. [PDF]

Commun Earth Environ
Nguyen D, Thanh PP, Burdett HL, Yaneva-Toraman I, Liao Z, Zou Q, Tu TQ, Dung LT, Huong LTT, Pereira R, Wagner T, Thi Thuy Ngo H, Kaiser MJ.   +12 more
europepmc   +1 more source

H2‐dependent modulation of tetrahydromethanopterin S‐methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei

The FEBS Journal, EarlyView.
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht, Bjarne Hastedt, Liam Cassidy, Claudia Kießling, Andreas Tholey, Jan M. Schuller, Ruth A. Schmitz   +6 more
wiley   +1 more source

Risk perception of the radiation health effects of decommissioning workers at Fukushima Daiichi Nuclear Power Plant. [PDF]

J Radiat Res
Matsunaga H, Zabirowa A, Liu M, Kashiwazaki Y, Orita M, Hande V, Takamura N.   +6 more
europepmc   +1 more source

Disruption of iron metabolism resulting from Dmt1/Slc11a2 deficiency compromises Notch protein degradation and transcriptional activation

The FEBS Journal, EarlyView.
Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock, Tom Keulers, Marc A. Vooijs   +5 more
wiley   +1 more source

Plutonium signatures in refractory fallout support a Chernobyl nuclear jet hypothesis. [PDF]

J Radioanal Nucl Chem
Joyce MJ, Boxall C, Christl M, Collins-Price P, Gaca P, Gautschi P, Livens F, Madina A, Semple KT, Warwick P, Wilbraham R.   +10 more
europepmc   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source