Results 111 to 120 of about 121,913 (303)
A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Advanced Science, EarlyView.This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu +16 more
wiley +1 more source
Wide range operation of advanced low NOx combustors for supersonic high-altitude aircraft gas turbines [PDF]
An initial rig program tested the Jet Induced Circulation (JIC) and Vortex Air Blast (VAB) systems in small can combustor configurations for NOx emissions at a simulated high altitude, supersonic cruise condition.
Fiorito, R. J., Roberts, P. B.
core +1 more source
Hydrocarbon emissions from a modern commercial airliner [PDF]
, 2006 We report selected carbon species emission indices (EIs) for a Rolls Royce RB211-535-E4 turbofan engine that were acquired during the NASA EXperiment to Characterize Aircraft Volatile Aerosol and Trace-species Emissions (EXCAVATE).
Anderson, BE, Blake, DR, Chen, G
core
Integrating Spatial Proteogenomics in Cancer Research
Advanced Science, EarlyView.Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang +13 more
wiley +1 more source
Advanced liner-cooling techniques for gas turbine combustors [PDF]
Component research for advanced small gas turbine engines is currently underway at the NASA Lewis Research Center. As part of this program, a basic reverse-flow combustor geometry was being maintained while different advanced liner wall cooling ...
Norgren, C. T., Riddlebaugh, S. M.
core +1 more source
Diffusion-controlled combustion [PDF]
, 2001 We devote this brief review to some relevant aspects of diffusion-controlled combustion. After a survey of the conservation equations involved, we shall describe the Burke-Schumann limit, which is applicable when the reaction time at the flame is very ...
Liñán Martínez, Amable
core +1 more source
Advanced Science, EarlyView.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
Results of the pollution reduction technology program for turboprop engines [PDF]
A program was performed to evolve and demonstrate advanced combustor technology aimed at achieving the 1979 EPA standards for turboprop engines (Class P2). The engine selected for this program was the 501-D22A turboprop.
Mularz, E. J.
core +1 more source
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Advanced Science, EarlyView.Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu +11 more
wiley +1 more source