Results 61 to 70 of about 501 (205)

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Influence of carbon dioxide addition on hydrogen-enriched diesel-WPO Blends in CI engines

Results in Engineering
Combustion engines are major contributors to environmental pollution. This study investigates carbon dioxide (CO₂) as a sustainable diluent in hydrogen-fueled engines to reduce emissions and improve combustion stability.
Prasshanth CV, Aditya Sai Samavedam, Manavalla Sreekanth, Tamilselvan P, TM Yunus Khan, Feroskhan M   +5 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Large Eddy Simulation of CO 2 diluted oxy-fuel spray flames

Fuel, 2017
We report results of a computational study of oxy-fuel spray jet flames. An experimental database on flames of ethanol burning in a coflow of a O 2–CO 2 mixture, created at CORIA (Rouen, France), is used for model validation (Cléon et al., 2015). Depending on the coflow composition and velocity the flames in these experiments start at nozzle (type A ...
Ma, L. (author), Huang, X. (author), Roekaerts, D.J.E.M. (author)   +2 more
openaire   +4 more sources

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Effects of inlet air holes on swirl flow characteristics and outlet temperature distribution in an axial swirl combustor

Case Studies in Thermal Engineering
The air inlet holes on the swirl combustor are crucial for high-performance micro gas turbine (MGT), affecting internal airflow, fuel-air mixing, temperature distribution, and cooling. However, there are seldom studies that pay attention to the influence
Yanzhao An, Shicheng Shen, Xueqing Fu, Yuzhang Wang, Yiqiang Pei, Yan Zhang, Chuang Chen   +6 more
doaj   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Burnup determination of natural uranium fuel by isotope dilution mass spectrometry and gamma spectroscopy

四川大学学报. 自然科学版, 2016
It is difficult that burnup determination of natural uranium fuel as to its lower burnup and less fission products. 137Cs was selected as the fuel burnup monitoring nuclide.
CHEN Yun-Ming, ZHANG Jin-Song, LIANG Bang-Hong, LI Bin, FENG Wei-Wei, ZHONG Jun, HU Yin, LIU ZHI, SUN Peng   +8 more
doaj  

INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY FOR THE DETERMINATION OF 237Np IN SPENT NUCLEAR FUEL SAMPLES BY ISOTOPE DILUTION METHOD USING 239Np AS A SPIKE

Nuclear Engineering and Technology, 2013
A determination method for 237Np in spent nuclear fuel samples was developed using an isotope dilution method with 239Np as a spike. In this method, inductively coupled plasma mass spectrometry (ICP-MS) was taken for the 237Np instead of the previously ...
KIHSOO JOE, SUN-HO HAN, BYUNG-CHUL SONG, CHANG-HEON LEE, YEONG-KEONG HA, KYUSEOK SONG   +5 more
doaj   +1 more source