Results 261 to 270 of about 5,051,565 (352)

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

The numerical reactor system for China's new-generation exascale supercomputer. [PDF]

Innovation (Camb)
Miao X, Wang J, Bai H, Wang Y, Wu Z, Lin Q, Zhang S, He X, Yang R, Nie N, Zhou C, Cao R, Wang Z, Hu Y, Yang W.   +14 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Optimizing the factors affecting the quality condition of 4WD tractors' engine oil using the hybrid RSM-GRA method. [PDF]

Sci Rep
Faregh SM, Afsharnia F, Dastjerdi RM.
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Experimental and ML-assisted optimization of injection timing and EGR in a diesel engine fueled with palmyra biodiesel. [PDF]

RSC Adv
Nair JN, Rao TS, Sreekara Reddy MBS, Raju VD, Venu H, Hadi AA, Smerat A, Khan TMY, Shaik AS, Khan MA.   +9 more
europepmc   +1 more source

Spatial distribution, contamination levels, and health risk of potentially toxic elements in surface soils of an industrial-urban area in northwestern Mexico: a case study from La Paz, Baja California Sur. [PDF]

Environ Geochem Health
Schiavo B, Valenzuela-Meza J, Valera-Fernández D, Inguaggiato C, Meza-Figueroa D, Morton-Bermea O.   +5 more
europepmc   +1 more source

Synchrotron radiation analysis of microparticles from the Fukushima Daiichi nuclear power station. [PDF]

Commun Chem
Kobayashi T, Kobata M, Tanida H, Okamoto Y, Fujimori SI, Takeda Y, Tsuji T, Fukuda T, Shibata G, Kawasaki I, Doi R, Okane T, Satou Y, Suzuki S, Maeda K, Yaita T.   +15 more
europepmc   +1 more source

Emerging Material Paradigm: Strategic Optimization of Spinel Oxides as High-Performance Air Electrodes for Nanostructured Ceramic Fuel Cells. [PDF]

Nanomaterials (Basel)
Hua M, Ge L.
europepmc   +1 more source

Influence of Fission Product Distribution in Medium-Burnup UO₂ Fuel on Cracking Behavior. [PDF]

Materials (Basel)
Xie D, Tang C, Fu T, Si J, Teng C, Wu L.
europepmc   +1 more source