Results 31 to 40 of about 63,160 (263)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Kinetic Modeling and Analysis of Fuel Element Pneumatic Lifting System in Pebble Bed Reactors
Applied Sciences, 2023 Thousands of fuel elements in pebble-bed reactor are lifted one by one from the bottom to the top of the core by pneumatic conveying every day. Any failure in the transportation process may lead to a safety accident.
Peng Shen +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Determination of plutonium and uranium content and burnup using six group delayed neutrons
Nuclear Engineering and Technology, 2019 In this study, investigation of spent fuel was performed using six group delayed neutron parameters. Three used fuels (F1, F2, and F11) which are burnt over the years in the core of Missouri University of Science and Technology Reactor (MSTR), were ...
T. Akyurek, S. Usman
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
SIMULATION OF ELECTRONIC EQUIPMENT ELEMENTS COOLING IN SOLIDWORKS
Advanced Engineering Research, 2010 Hand in hand with the integration increase of the up-to-date radio electronic equipment (REE) there grows substantially its design complexity, which is associated with an increase in the dimension of the problems solved in the development process. The
Arkady N. SOLOVIEV, Leila V. GLAZUNOVA
doaj
The approach to determining vulnerable elements in critical energy infrastructures [PDF]
E3S Web of Conferences, 2019 The paper presents the main provisions of the methodology for identifying vulnerable elements in the fuel and energy complex, which is studied as a set of industry critical energy infrastructures.
Beresneva Natalia, Pyatkova Natalia
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source