Results 101 to 110 of about 63,387 (305)

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

open access: yesAdvanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang   +10 more
wiley   +1 more source

Investigation of split injection in a single cylinder optical diesel engine

open access: yes, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Over the last decade, the diesel engine has made dramatic progress in its performance and market penetration.
Díez Rodríguez, Álvaro
core  

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang   +16 more
wiley   +1 more source

Experimental investigation of gasoline – Dimethyl Ether dual fuel CAI combustion with internal EGR

open access: yes, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A new dual fuel Controlled Auto-Ignition (CAI) combustion concept was proposed and researched for lower exhaust emissions and better fuel economy.
Zhang, Haofan
core  

Design and investigation of a diesel engine operated on pilot ignited LPG [PDF]

open access: yes, 2009
This thesis explores the idea of igniting LPG in a compression ignition diesel engine using pilot diesel injection as spark ignition medium. The main advancement in using this technology on current diesel engines is the establishment of a better ...
Theodoridis, Eudoxios
core  

An Experimental Characterization for Injection Quantity of a High-pressure Injector in GDI Engines

open access: yesJournal of Low Power Electronics and Applications, 2018
The high-pressure (HP) injector is a highly dynamic component requiring careful voltage and pressure input modulation to achieve the required fuel injection quantities of gasoline direct injection (GDI) engines.
Wen-Chang Tsai, Tung-Sheng Zhan
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

open access: yesAdvanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao   +12 more
wiley   +1 more source

Combustion Characteristics of CI Engine Running with Biodiesel Blends

open access: yes, 2011
Biodiesel is one of the promising renewable, alternative and environmentally friendly biofuels that can be used in diesel engine with little or no modification in the engine.
Gu, Fengshou   +11 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

open access: yesAdvanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei   +11 more
wiley   +1 more source

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