Results 41 to 50 of about 109,100 (269)

Proton membrane fuel cell stack performance prediction through deep learning method

open access: yesEnergy Reports, 2022
Proton exchange membrane fuel cell (PEMFC) system is a complex non-linear system affected by many factors with interaction, which make it difficult to build an accurate mathematical model to predict the fuel cell performance.
Jiangtao Fu, Zhumu Fu, Shuzhong Song
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Full-core high-burnup BWR LOCA fuel performance analysis and FFRD susceptibility

open access: yesFrontiers in Nuclear Engineering
The susceptibility of the boiling water reactor (BWR) Limerick Unit 1 to fuel fragmentation, relocation, and dispersal during a postulated large-break loss-of-coolant accident (LBLOCA) was calculated using a multiphysics framework.
Ian Greenquist   +11 more
doaj   +1 more source

The micro-scale modeling by experimental study in PEM fuel cell

open access: yesJournal of Thermal Engineering, 2017
This study posed parameters effects to the PEM fuel cell performance by an experimental work. The aim of this study is to investigate performance effects of PEM fuel cells and to optimize water conditions as well as fuel cell performance. Platinum-plated
Tolga Taner
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Validation of the fuel rod performance analysis code FRIPAC

open access: yesNuclear Engineering and Technology, 2019
The fuel rod performance has great importance for the safety and economy of an operating reactor. The fuel rod performance analysis code, which considers the thermal-mechanical response and irradiation effects of fuel rod, is usually developed in order ...
Yong-Jun Deng   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Preliminary design of SiC composite cladding fuel rod with lead-bismuth eutectic filled pellet-cladding gap

open access: yesHe jishu
BackgroundThermal conductivity of SiC composite cladding significantly decreases after irradiation, leading to cladding failure due to high tensile stress under pellet-cladding mechanical interaction (PCMI).PurposeThis study aims to address the ...
ZHANG Ruixiao   +6 more
doaj   +1 more source

Investigation of the Effects of Working Conditions on Performance of Planar and Cylindrical Proton Exchange Membrane Fuel Cells

open access: yesGlobal Challenges, 2023
In this study, the effects of varying operating conditions on cell performance in cylindrical and planar PEM (Proton Exchange Membrane) fuel cells with equal geometrical properties are investigated numerically.
Muhammed Salih Cellek, Tolga Demircan
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

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