Results 31 to 40 of about 1,388,565 (276)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Energy Poverty in Europe: A Multidimensional Approach
PSL Quarterly Review, 2017 With the European Commission’s “Third Energy Package”, the challenges posed by energy poverty have been recently acknowledged by European legislation.
Carlo Andrea Bollino, Fabrizio Botti
doaj +3 more sources
Atmosphere, 2022 In accordance with national regulations, the renovation of the residential sector is an urgent task for achieving significant reductions in energy consumption and CO2 emissions of the existing building stock.
Adriana Ciardiello +5 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Energies, 2020 Energy poverty—involving a combination of factors, such as low household incomes, high energy prices, and low levels of residential energy efficiency—is identified as a complex and increasing issue affecting people’s physical health ...
Danila Longo +4 more
doaj +1 more source
Addressing Multidimensional Energy Poverty Implications on Achieving Sustainable Development
Energies, 2023 This study examines whether shifts in the stance of policymaking can account for the observed predictability in excess energy poverty (EP) or fuel poverty (FP) levels.
George E. Halkos +1 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Achieving deep-energy retrofits for households in energy poverty
Buildings & Cities, 2023 Climate change and energy poverty are two sustainability challenges that can be addressed through deep-energy retrofits for homes. This systematic review identifies which factors influence the achievement of energy retrofits for households vulnerable to ...
Laura Tozer, Hannah MacRae, Emily Smit
doaj +1 more source