Results 71 to 80 of about 22,615,899 (301)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Sensitivity analysis of parameters affecting carbon footprint of fossil fuel power plants based on life cycle assessment scenarios [PDF]

Global Journal of Environmental Science and Management, 2017
In this study a pseudo comprehensive carbon footprint model for fossil fuel power plants is presented. Parameters which their effects are considered in this study include: plant type, fuel type, fuel transmission type, internal consumption of the plant ...
F. Dalir, M. Shafiepour Motlagh, K. Ashrafi   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Emission Inspections of Vehicles in Operation—Case Study for Slovakia

Vehicles
Air pollution poses a serious threat to human health and the environment. Emissions from motor vehicles, especially in large cities, contribute significantly to this problem.
Miloš Poliak, Michal Loman, Roman Stovička   +2 more
doaj   +1 more source

Fuel type estimation using fuel system parameters [PDF]

, 2016
A number of factors are responsible for an increased interest in alternative fuels for transportation and other uses. Among the most widely available alternative fuels are biodiesel and vegetable oil, both of which can be used to power a diesel engine ...
Balasubramanian, Shambhavi
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Simple Spread Models for Understory Surface Fires

Fire
Surface fire frequently occurs beneath the canopy of North American forests under moderate wind speed and moisture-deficit conditions. Surface rate of spread (sROS) models can provide guidance for suppression operations and can be incorporated into fire ...
Daniel D. B. Perrakis, Nicholas J. R. Hebda, S. W. Taylor   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A case study analysis of system efficiency, viability and energy values of SOFC based fuel cell Micro-CHP for office buildings [PDF]

, 2015
The built environment is a large contributor to the greenhouse gas emissions. The first step in tackling environmental impact and fuel cost reduction is the minimization of energy losses through introduction of new and more efficient energy conversion ...
Mylona, A., Irvine, John Thomas Sirr, Connor, Paul Alexander, Cassidy, Mark, Tesfai, Alem, Connor, Paul Alexander; id_orcid, Irvine, John Thomas Sirr; id_orcid   +6 more
core   +1 more source