Results 41 to 50 of about 5,066,137 (145)

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

MRI Proton Density Fat Fraction as a Biomarker of Marrow Recovery Following Organ‐Sparing Total Marrow Irradiation in Sickle Cell Disease

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Noninvasive quantitative assessment of marrow recovery after curative therapies such as total marrow irradiation (TMI) and bone marrow transplantation (BMT) remain poorly defined, particularly in sickle cell disease (SCD). Purpose To evaluate MRI‐derived proton density fat fraction (PDFF) as a biomarker of marrow recovery following ...
Malakeh Malekzadeh, Hemendra Ghimire, Ji Eun Lim, Srideshikan S. Madabushi, Weidong Hu, Marco Andrea Zampini, Kazuki Fujita, Raghda Fouda, Guy Storme, Joo Song, Bihong T. Chen, Anna Pawlowska, Susanta K. Hui   +12 more
wiley   +1 more source

Challenging the Gender Status Quo: How Low Gender System Justification Predicts Pro‐Women Leadership Bias

Journal of Organizational Behavior, EarlyView.
ABSTRACT We offer a new perspective on gender‐based biases in leadership evaluations by examining individual differences in beliefs about the gender status quo. Specifically, across three studies (N = 756), we tested how gender system‐justifying beliefs interact with leader gender to impact leadership evaluations.
Crystal L. Hoyt, Jeni L. Burnette, Eve Ridenhour, Julia Griffin   +3 more
wiley   +1 more source

Kinetic Study on the Reaction of Phenylperoxy Radicals With Nitric Oxide

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT Cavity ring‐down spectroscopy (CRDS) and quantum cascade laser absorption spectroscopy (QCLAS), in conjunction with pulsed laser photolysis, were employed to investigate the reaction between phenylperoxy radicals (C6H5O2) and nitric oxide (NO) at a temperature of 296 ± 4 K. The experiment was carried out under N2 as bath gas.
Maya Matsushita, Michiya Fujita, Kenichi Tonokura   +2 more
wiley   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Improving Welding Behavior of ETPU Bead Foams by Surface Modification with Plasticizers

Journal of Polymer Science, EarlyView.
Tributyl citrate (TBC) and stearic acid (SA) modify ETPU beads through different diffusion mechanisms. TBC diffuses the bead structure directly after coating, whereas SA remains on the surface until melting and subsequent diffusion during heating. The resulting plasticization improves bead fusion, allowing RF processing at reduced temperature and ...
Alexander Himsel, Marcel Dippold, Makrina Chairopoulou, Maximilian Drexler, Holger Ruckdäschel   +4 more
wiley   +1 more source

Genomic insights into the local adaptation of spontaneous olive trees in the Mediterranean Basin highlight the need for conservation planning in the face of global change

PLANTS, PEOPLE, PLANET, EarlyView.
The Mediterranean Basin, a major biodiversity hotspot, is highly vulnerable to climate and global changes. Wild olive trees form an essential part of this landscape and hold strong ecological, cultural and socio‐economic significance. By examining how these trees responded to past climatic conditions, this study shows adaptation of olive trees to local
Lison Zunino, Gautier Sarah, Lorenzo Rocchetti, Bénédicte Rhoné, Alexandre Soriano, Gaëtan Droc, Pierre Mournet, Ahmed El Bakkali, Evelyne Costes, Bouchaib Khadari, Philippe Cubry   +10 more
wiley   +1 more source

Clinical Outcomes and Acute Exacerbation Incidence in Combined Pulmonary Fibrosis and Emphysema

Respirology, EarlyView.
This multicentre prospective study of 1016 patients demonstrated that CPFE, defined as ≥ 5% emphysema on visual CT assessment, identified a high‐risk phenotype with significantly worse 5‐year survival compared to non‐CPFE IIP patients (51.4% vs. 63.1%) and COPD patients (51.4% vs. 84.0%) and higher acute exacerbation incidence, validating international
Kazuya Tsubouchi, Yasuaki Kotetsu, Tomotsugu Takano, Hiroaki Ogata, Fumiaki Kiyomi, Katsuyuki Ichiki, Shohei Takata, Yasuhiko Kitasato, Hiroshi Ishii, Kazuhiro Yatera, Kei Yamasaki, Masaki Okamoto, Makoto Yoshida, Masayuki Kawasaki, Masaki Fujita, Tomohiro Ogawa, Kazunori Tobino, Eiji Harada, Noriaki Nakagaki, Masashi Komori, Taishi Harada, Hiroshi Wataya, Yoichi Nakanishi, Isamu Okamoto   +23 more
wiley   +1 more source

Validation of a Particle Image Velocimetry Algorithm Through Comparative Field and Laboratory Analysis

River Research and Applications, EarlyView.
ABSTRACT Flow velocity measurement is fundamental to hydrological and hydraulic studies, providing essential data for streamflow estimation and river dynamics analysis. Traditional in situ methods like propeller gauges and acoustic Doppler current profilers are accurate but intrusive and labour‐intensive, while non‐intrusive image processing methods ...
Ghazaleh Nassaji Matin, Gareth Bradbury, Alan Puttock, Kirsty Frith, Diego Panici   +4 more
wiley   +1 more source