Results 51 to 60 of about 43,749 (259)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Single-Carrier Delay-and-Superposition Based High Spectral Efficiency Differential Chaos Shift Keying for Maritime Internet of Vessels

IEEE Access, 2022
The fast growing Internet of Vessels (IoV) requires maritime communications to be more spectral efficient to make full use of the scarce maritime spectral resource, provide a high data transmission rate and support massive communication nodes to access ...
Xinyu Dou, Tengxiao Lyu, Baojun Fan, Dequn Liang   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Next generation multi-screen interactive technology system of smart home based on TV screen

Dianxin kexue, 2018
With the full popularity of internet technology and the rapid development of video services,video content has become the current home entertainment protagonist.With the diversity of terminals and the improvement of display technology,the carrier of video
Weijia SHI, Zheng WEI, Guqiao ZHU
doaj   +2 more sources

Multi-Mode Lasers for Self-Forced Opto-Electronic Oscillators in Compact Frequency Synthesizers

IEEE Journal of Microwaves, 2021
Advanced telecommunication, imaging, and remote sensing systems require reliable ultra-high stability local oscillators. Particularly, coherent detection of digital data signals relies on a low aperture jitter of local oscillators in addition to high ...
Afshin S Daryoush, Tianchi Sun
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Are low cost carriers airfares still lower? A comparison with full service carriers in Europe

Journal of the Air Transport Research Society
The main objective of this work is to contribute to the existing literature on the effects of competition from Low-Cost Carriers on airfares in the European non-stop market. To the best of our knowledge, this is the first paper describing the impact of the operations of LCCs on ticket prices in Europe using data from real transactions (i.e., passengers
Gualini, Andrea, Martini, Gianmaria, Porta, Flavio   +2 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

A Coming Singularity in Media Regulation: The American Case

International Journal of Communication, 2017
The singularity identified in this article is the prospect that the cable-based Internet service provider could potentially become the sole vendor capable of providing truly high-speed residential broadband connectivity in the United States. The premise
W. Russell Neuman
doaj   +2 more sources