Results 231 to 240 of about 810,157 (316)

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles. [PDF]

Saudi Pharm J, 2015
Kumar L, Sreenivasa Reddy M, Managuli RS, Pai K G.   +3 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Nanoemulsions containing a synthetic chalcone as an alternative for treating cutaneous leshmaniasis: optimization using a full factorial design. [PDF]

Int J Nanomedicine, 2015
de Mattos CB, Argenta DF, Melchiades Gde L, Cordeiro MN, Tonini ML, Moraes MH, Weber TB, Roman SS, Nunes RJ, Teixeira HF, Steindel M, Koester LS.   +11 more
europepmc   +1 more source

Does the Application Flow Rate of Nutrient Solutions Prepared in Brackish Water Affect Coriander Production?

Irrigation and Drainage, EarlyView.
ABSTRACT Flow rates for applying nutrient solutions in hydroponic systems are empirically known, yet uncertainties remain regarding whether brackish water affects the optimal flow rate and, consequently, biomass production and allocation. This study evaluated whether variations in application flow rate affect coriander biomass when brackish water is ...
Raphaela Revorêdo Bezerra, Uriel Calisto Moura Pessoa, Ênio Farias de França e Silva, Tarcísio Ferreira de Oliveira, Thieres George Freire da Silva, Nildo da Silva Dias, José Fernandes Ferreira Junior, José Amilton Santos Júnior   +7 more
wiley   +1 more source

Similarity and substitution: Using pile sorting methods to explore economic behavior

Journal of the Agricultural and Applied Economics Association, EarlyView.
Abstract Despite the common intuition that similar products are stronger demand substitutes, this study shows a more nuanced relationship between perceived similarity and utility substitution. Using pile sorting, a method where items are sorted into groups according to their similarity, we conduct large‐scale consumer surveys on purchasing 21 foods for
Jayson L. Lusk, Vincenzina Caputo, Amelia Ahles   +2 more
wiley   +1 more source

Dissolution rate improvement of telmisartan through modified MCC pellets using 3² full factorial design. [PDF]

Saudi Pharm J, 2016
Patel H, Patel H, Gohel M, Tiwari S.
europepmc   +1 more source

They Hold Me Back: The Dynamic Interplay of Parental Discouragement of Exploration, Parental Metaemotion and Adolescent's Sense of Agency

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescence is a critical developmental period characterized by increasing needs for autonomy and identity exploration. However, limited research has examined how adolescents perceived parental discouragement of exploration over time.
Filipa Nunes, Catarina Pinheiro Mota, Tiago Ferreira, Ingrid Schoon, Paula Mena Matos   +4 more
wiley   +1 more source

Immunomodulatory and Cytotoxic Properties of Enniatin B1 in Porcine Alveolar Macrophages

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study investigates the immunomodulatory effects of Enniatin B1 (ENNB1), an emerging mycotoxin, on porcine alveolar macrophages (PAMs), a species‐specific model relevant to human innate immunity. PAMs were exposed to increasing ENNB1 concentrations (0.5–6 μM) over 6, 24, and 48 h.
Sara Frazzini, Francesca Caloni, Paola Fossati, Giancarlo Ruffo, Luciana Rossi   +4 more
wiley   +1 more source

The Role of Self‐Compassion and Experience in Psychologists' Latent Emotional Labour Strategy Profiles

Journal of Clinical Psychology, EarlyView.
ABSTRACT Objective Emotional labour has long been associated with personal and organizational outcomes such as burnout. However, theoretically dichotomising regulation into surface and deep acting may constrain the ecological validity of research as iterative and person‐centered approaches to emotion regulation are not considered.
James J. Clarke, Vincent O. Mancini, Clare S. Rees, Lauren J. Breen   +3 more
wiley   +1 more source