Results 51 to 60 of about 16,868 (267)

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Prospective harmonisation of four international randomised controlled trials in Canada, China, India and South Africa: the Healthy Life Trajectories Initiative [PDF]

Objectives The Healthy Life Trajectories Initiative (HeLTI) is an international multistudy consortium that supports the development and integration of four randomised controlled trials (RCTs) conducted in South Africa, India, China and Canada. HeLTI aims
Samuel El Bouzaïdi Tiali, Julie Bergeron, Kalyanaraman Kumaran, William Fraser, Stephen G Matthews, Cindy Lee Dennis, Flavia Marini, Anouar Nechba, Isabel Fortier, Stephen Lye, Catherine Birken, Catherine Draper, Elizabeth A Bojarski, He-Feng Huang, Shane A Norris, Nadia Abdelouahab, Stephanie Atkinson, Ghattu V Krishnaveni, Rayjean Hung, Jianxia Fan, Jean-Patrice Baillargeon   +20 more
core   +1 more source

Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction A rapid transition from a clinical‐based classification to a pathology‐based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging.
Daniela Perani, Leonardo Iaccarino, Andreas H. Jacobs, IMBI Brain Imaging Working Group, Adriaan A. Lammertsma, Agneta Nordberg, Albert D. Windhorst, Alexander Gerhard, Alexandra Winkeler, Andreas H. Jacobs, Anthony Gee, Bertrand Kuhnast, Christer Halldin, Daniela Perani, David Brooks, Elena Rodriguez‐Vieitez, Federico E. Turkheimer, Francisco López‐Picón, Gitte M. Knudsen, Johnny Vercouillie, Juha O. Rinne, Karl Herholz, Koen Van Laere, Andrea Varrone, Marie Joao Santiago‐Ribeiro, Matthias M. Herth, Michael A. Carroll, Sylvie Chalon, Michel Bottlaender, Oskar Hansson, Paul Edison, Rainer Hinz, Ronald Boellaard, Rosa Maria Moresco, Sabina Pappata   +34 more
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

An analysis of humanitarian and health aid harmonisation over a decade (2011–2019) of the Syrian conflict [PDF]

Introduction Aid harmonisation is a key component of donor efforts to make aid more effective by improving coordination and simplifying and sharing information to avoid duplication. This study evaluates the harmonisation of health and humanitarian aid in
Abbara, Aula, Abdulkarim Ekzayez, Munzer Alkhalil, Meagher, Kristen, El Achi, Nassim, Zedoun Al Zoubi, Rim Turkmani, Alaref, Maher, Ekzayez, Abdulkarim, Nassim El Achi, Maher Alaref, Al Zoubi, Zedoun, Preeti Patel, Patel, Preeti, Kristen Meagher, Alkhalil, Munzer, Turkmani, Rim, Aula Abbara   +17 more
core   +1 more source

Harmonisation through Neglect: The Federal Nature of European Employment Policy [PDF]

, 2005
This paper proposes using the methodological perspective of critical federalism, constructed by merging the theoretical framework of critical political economy with the analytical approach of co-operative federalism, to understand the harmonisation and ...
Preece, Daniel V.
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Harmonising French and German administrative DADS-EDP and SIAB data

Journal for Labour Market Research
Administrative data are increasingly used in social science research, including for studying the labour market consequences of motherhood. Yet despite the growing use of such data within countries, cross-national comparative research remains limited ...
Andreas Filser, Pascal Achard, Inga Marie Amend, Corinna Frodermann, Ida Gaede, Sander Wagner   +5 more
doaj   +1 more source

DoE-Assisted Development of a Novel Glycosaminoglycan-Based Injectable Formulation for Viscosupplementation

Pharmaceutics, 2020
The aim of the present work was the development of a novel glycosaminoglycan (GAG)-based injectable formulation intended for intra-articular administration that should best mimic the healthy synovial fluid.
Marta Cicognani, Silvia Rossi, Gabriele Vecchi, Andrea Maria Giori, Franca Ferrari   +4 more
doaj   +1 more source