Results 121 to 130 of about 10,589,432 (340)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Full Length Research Paper Production of emodin from Aspergillus ochraceus at preparative scale

African Journal of Biotechnology, 2012
In order to study the chemical constituents in the pigmented culture produced from Aspergillus ochraceus, solid phase extraction method was employed to isolate the pigment molecules from the primary culture, followed by fractionation on preparative liquid chromatography.
Lu, P, Zhao, X, Cui, T
openaire   +1 more source

"Mirror Image" space charge distribution in XLPE power cable under opposite stressing voltage polarity [PDF]

, 2005
The paper presents the research on space charge distribution under different polarities in full size cross-linked polyethylene power cables using the pulsed electro-acoustic technique.
Chen, G., Fothergill, J., Fu, M.
core  

Green Human Resource Management: A Review and Research Agenda

, 2013
The paper makes a case for the integration of the largely separate literatures of environmental management (EM) and human resource management (HRM) research.
D. E. Renwick, T. Redman, S. Maguire
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Fundamental questions in meiofauna research highlight how small but ubiquitous animals can improve our understanding of Nature

Communications Biology
This paper identifies the top-50 priority questions for meiofaunal research, highlighting their critical roles in biogeochemical cycles and biodiversity.
Alejandro Martínez, Stefano Bonaglia, Maikon Di Domenico, Gustavo Fonseca, Jeroen Ingels, Katharina M. Jörger, Christopher Laumer, Francesca Leasi, Daniela Zeppilli, Elisa Baldrighi, Holly Bik, Diego Cepeda, Marco Curini-Galletti, Asher D. Cutter, Giovanni dos Santos, Simone Fattorini, Dagmar Frisch, Sabine Gollner, Ulf Jondelius, Alexandra Kerbl, Kevin M. Kocot, Nabil Majdi, Stefano Mammola, José M. Martín-Durán, André Menegotto, Paul A. Montagna, Francisco J. A. Nascimento, Nicolas Puillandre, Anne Rognant, Nuria Sánchez, Isaac R. Santos, Andreas Schmidt-Rhaesa, Michaela Schratzberger, Federica Semprucci, Mauricio Shimabukuro, Paul J. Sommerfield, Torsten H. Struck, Martin V. Sørensen, Andreas Wallberg, Katrine Worsaae, Hiroshi Yamasaki, Diego Fontaneto   +41 more
doaj   +1 more source

Clusters, human capital and economic development in Oxfordshire and Cambridgeshire [PDF]

, 2012
Oxfordshire and Cambridgeshire are two of the most high tech economies in the UK (see for example DTI, 2002 and Garnsey and Lawton Smith, 1998). They are home to world class research universities and public and private research laboratories as well as a ...
Lawton-Smith, Helen, Waters, R.
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

RETRACTED: Pain predicts poorer health-related quality of life in childhood-onset systemic lupus erythematosus: a cohort study

Journal of International Medical Research, 2018
At the request of the Journal’s Editor, the Publisher and the authors, the following article has been retracted. Li J, Jones JT, Donnelly C, Cunningham N, Kashikar-Zuck S and Brunner HI.
Ji Li, Jordan T. Jones, Catherine Donnelly, Natoshia Cunningham, Susmita Kashikar-Zuck, Hermine I. Brunner   +5 more
doaj   +1 more source