Results 111 to 120 of about 9,794,120 (297)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

RANS analysis of the self-propulsion performance for a twin-screw ship

International Journal of Naval Architecture and Ocean Engineering
This study presents a comprehensive estimation of full-scale self-propulsion performance for a high-speed, twin-screw, single-skeg surface vessel using Reynolds-averaged Navier–Stokes (RANS)-based computational fluid dynamics (CFD). Resistance, propeller
Je-In Kim, Bu-Geun Paik, Jong-Woo Ahn, Il-Ryong Park   +3 more
doaj   +1 more source

Progress towards an american full scale environmental design simulation laboratory (SIM-LAB)

, 1987
The need for a hands-on, full scale mock-up facility where elements of the man-made environment can be tried out before being built has recently become of considerable concern to people from a wide range of fields.
B. Kjaer
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Characterisation of recycled mixed plastic solid wastes : Coupon and full-scale investigation

, 2016
In Australia, the plastic solid waste (PSW) comprises 16% by weight of municipal solid waste but only about one-fourth are recycled. One of the best options to increase the recycling rate of mixed PSW is to convert them into products suitable for ...
Manalo, Allan C., Bajracharya, RM, Karunasena, W, Bajracharya, Rohan Muni, Lau, KT, Karunasena, Warna, Manalo, AC, Lau, Kin-tak   +7 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Characterization of full-scale denial-of-service

International Journal of Control
This article investigates the resilient control problem for Cyber-Physical Systems (CPSs) with multiple sensors, where both sides of the communication channels are affected by Denial-of-Service (DoS) attacks. While previous work focused on characterizing Multi-Channel DoS (MCDoS), this study emphasizes the characterization of Full-Scale DoS (FSDoS ...
Anindya Basu, Indrani Kar
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source