Results 31 to 40 of about 329,549 (313)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Fracture-Safe and Fatigue-Reliable Structures [PDF]

Fracture and Structural Integrity, 2014
Learning from history is, by popular account, something at which human beings are not particularly good; George Bernard Shaw having stated that “we learn from history that we learn nothing from history”, while the Spanish philosopher George Santayana ...
M. N. James
doaj   +2 more sources

Disease activity and cognition in rheumatoid arthritis : an open label pilot study [PDF]

, 2012
Acknowledgements This work was supported in part by NIHR Newcastle Biomedical Research Centre. Funding for this study was provided by Abbott Laboratories.
Birchall, Daniel, Blamire, Andrew M, He, Jiabao, Isaacs, John D, Newton, Julia L, Pearce, Ruth, Raftery, Graham   +6 more
core   +1 more source

Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim, Han Gil Seo, Roh‐Eul Yoo, Byung‐Mo Oh   +3 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Ultrasonic VHCF Tests on Very Large Specimens with Risk-Volume Up to 5000 mm³

Applied Sciences, 2020
The research on the size-effects in Very-High-Cycle Fatigue (VHCF) has recently drawn the attention of several scholars. The fatigue cracks in VHCF originate from the largest defect present within the loaded material volume (risk-volume) and the larger ...
Andrea Tridello, Davide Salvatore Paolino, Massimo Rossetto   +2 more
doaj   +1 more source

Wires for spring construction: full scale fatigue experimental tests

Meccanica, 2021
The paper deals with the experimental assessment of the fatigue life of wires for spring construction. Fatigue testing of full-scale wires is not a well established procedure. The aim of the paper is to demonstrate that the fatigue properties of full-scale wires for spring construction can be assessed with a level of accuracy comparable with tests ...
Ballo, F., Carboni, M., Mastinu, G., Previati, G.   +3 more
openaire   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A laboratory study on cold-mix, cold-lay emulsion mixtures [PDF]

, 2009
This paper describes laboratory experiments and presents results for the performances of cold-mix, cold-lay emulsion mixtures. The main objective of the experiments was to evaluate and improve the properties of the cold mixtures.
Aderson A., Asphalt Institute, British Standards Institution, British Standards Institution, British Standards Institution, British Standards Institution, British Standards Institution, Cooper K. E., Energy Efficiency Office of the Department of the Environment, Highway Authorities and Utilities Committee (HAUC), I. N. A. Thanaya, J. P. Forth, Leech D., Milton L. J., Ministry of Public Works Republic of Indonesia (MPW-RI), Nichols J. C., Nikolaides A. F., Nikolaides A. F., Pascoe R. D., S. E. Zoorob, Suparma L. B., Thanaya I. N. A., Whitoeak D., Zoorob S. E.   +23 more
core   +1 more source