Results 61 to 70 of about 329,549 (313)

Non-local energy based fatigue life calculation method under multiaxial variable amplitude loadings [PDF]

, 2013
Reliable design of industrial components against high cycle multiaxial fatigue requires a model capable of predicting both stress gradient and load type effects. Indeed, taking into account gradient effects is of prior importance for the applicability of
BÉNABÈS, Jérôme, COCHETEUX, Francis, PALIN-LUC, Thierry, SAINTIER, Nicolas   +3 more
core   +6 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Influence of the Fatigue Load Level and the Hole Diameter on the Laminate Structure’s Fatigue Performance

Fatigue of Aircraft Structures, 2018
Damage tolerance of composite aircraft structure is one of the main areas of research, important when a new product is being developed. There are a number of variables, such as damage characteristics (dent depth, delamination area) and loading parameters
Zalewska Małgorzata
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Modal Analysis of Marine Pipeline Based on Full-scale Fatigue Test System

Shiyou jixie, 2018
In the past, the full-scale fatigue tests of marine pipelines were mostly focused on the bending fatigue. Considering the uneven circumferential force on the pipeline weld and the prolonged test period, the resonance principle is proposed for the fatigue
Liang Ke, Hu Yanhua, Tang Deyu, Fan Jianchun, Zhang Zhiyuan   +4 more
doaj  

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Fatigue Life Assessment of Railway Rails with Lubrication Holes: Experimental Validation and Finite Element Modelling

Metals
This study investigates the fatigue behavior of railway rails with lubrication holes through a finite element modeling approach validated against full-scale laboratory tests.
Jose Sainz-Aja, Pablo San Roman, Jose A. Casado, Isidro Carrascal, Borja Arroyo, Diego Ferreño, Raul Moreno, David Peribañez, Hugo Vegas, Soraya Diego   +9 more
doaj   +1 more source

A proposed USAF fatigue evaluation program based upon recent systems experience [PDF]

The United States Air Force has published a document entitled Aircraft Structural Integrity Program. One phase of the program is concerned with the fatigue life certification of all types of military aircraft.
Haviland, G. P., Purkey, G. F.
core   +1 more source

Reinforcing a Notched Steel Girder End by Steel Plate Pre-Stressing [PDF]

, 2006
The applicability of the steel plate pre-stressing method is investigated for the purpose of preventing fatigue crack propagation to the web in the notched girder end.
Matsumoto Kentaro, Namiki Hironori, Sakano Masahiro, 並木 宏徳, 坂野 昌弘, 松本 健太郎   +5 more
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source