Results 21 to 30 of about 1,711,763 (306)

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK

eLife, 2020
Bruton’s tyrosine kinase (BTK) is targeted in the treatment of B-cell disorders including leukemias and lymphomas. Currently approved BTK inhibitors, including Ibrutinib, a first-in-class covalent inhibitor of BTK, bind directly to the kinase active site.
Raji E Joseph, Neha Amatya, D Bruce Fulton, John R Engen, Thomas E Wales, Amy Andreotti   +5 more
doaj   +1 more source

Adaptive models of short-term surface subsidence prediction and detection of the most hazardous building position in displacement trough [PDF]

Инженерно-строительный журнал, 2013
Surface subsidence prediction is needed to evaluate mechanical safety and make it possible to provide further operation of buildings located in subsided area.
A.V. Vorobev, G.G. Kashevarova
doaj   +1 more source

A novel simulation framework to estimate dynamic response of a solar panel array under stationary stochastic wind loads

Frontiers in Built Environment
This paper presents a novel simulation framework for estimating the dynamic response of a full-scale ground-mounted solar panel array under stationary wind loads that are spatially correlated across the length of the solar panel array.
Hanshu Zhang, You-Jia Li, Matthew J. DeJong   +2 more
doaj   +1 more source

Investigating the Effect of the Number of End-Panel Studs on the Seismic Properties of Cold-Formed Light-Steel Shear-Panel Braces

Archives of Civil Engineering, 2013
Detailed investigation of the effect of the number of end-panel studs on the seismic properties of light-steel shear-panel braces in cold-formed steel frames and in particular the associated response modification coefficients (R) factor, are presented in
Tafti Mohammad Reza Javaheri, Behnamfar Farhad   +1 more
doaj   +1 more source

Clinical Applications of Quantitative Perfusion Imaging with a C-Arm Flat-Panel Detector—A Systematic Review

Diagnostics, 2022
C-arm systems with digital flat-panel detectors are used in interventional radiology and hybrid operating rooms for visualizing and performing interventions on three-dimensional structures.
Abdallah H. A. Zaid Al-Kaylani, Richte C. L. Schuurmann, Wouter D. Maathuis, Riemer H. J. A. Slart, Jean-Paul P. M. De Vries, Reinoud P. H. Bokkers   +5 more
doaj   +1 more source

Underwater blast loading of partially submerged sandwich composite materials in relation to air blast loading response

International Journal of Lightweight Materials and Manufacture, 2020
The research presented in this paper focusses on the underwater blast resilience of a hybrid composite sandwich panel, consisting of both glass-fibre and carbon-fibre.
Emily Rolfe, Robert Quinn, George Irven, David Brick, John P. Dear, Hari Arora   +5 more
doaj   +1 more source

Seismic Performance of Full-Scale Autoclaved Aerated Concrete Panel-Assembled Walls: Experimental Study and Numerical Modeling

Buildings
Prefabricated panel-assembled wall systems, comprising a confining frame and infill lightweight panels of autoclaved aerated concrete (AAC), are widely employed in framed structures.
Xiaowei Li, Dongwen Ma, Qidi Zhang, Zhaoqiang Zhang, Han Bao, Yong Yao   +5 more
doaj   +1 more source

Experimental study on effect of ductile-iron panel stiffness on mechanical properties of segmental joints of shield tunnels

Underground Space, 2022
In circular shield tunnels bearing high inner pressure or rectangular shaped shield tunnels, as the axial force at the segmental lining decreases, the bolt load at the segmental joint increases. It is essential to adopt high-stiffness segmental joints to
Long Zhou, Zhiguo Yan, Yi Shen, Linxing Guan   +3 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Experimental Tests on Bending Behavior of Profiled Steel Sheeting Dry Board Composite Floor with Geopolymer Concrete Infill

Latin American Journal of Solids and Structures
Profiled Steel Sheet Dry Board (PSSDB) system is a lightweight composite structure comprises Profiled Steel Sheeting and Dry Board connected by self-drilling and self-tapping screws.
Mohd Isa Jaffar, Wan Hamidon Wan Badaruzzaman, Shahrizan Baharom   +2 more
doaj   +1 more source