Results 1 to 10 of about 48 (45)

SON-1210 - a novel bifunctional IL-12 / IL-15 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy [PDF]

Frontiers in Immunology, 2023
BackgroundThe potential synergy between interleukin-12 (IL-12) and IL-15 holds promise for more effective solid tumor immunotherapy. Nevertheless, previous clinical trials involving therapeutic cytokines have encountered obstacles such as short ...
John K. Cini, Susan Dexter, Darrel J. Rezac, Stephen J. McAndrew, Gael Hedou, Rich Brody, Rukiye-Nazan Eraslan, Richard T. Kenney, Pankaj Mohan   +8 more
doaj   +2 more sources

Bordetella pertussis and Bordetella bronchiseptica filamentous hemagglutinins are processed at different sites. [PDF]

FEBS Open Bio, 2018
Filamentous hemagglutinins (FHA) of Bordetellae are produced by processing of the ~ 130‐kDa C‐terminal prodomains of their FhaB precursors by the subtilisin‐like protease SphB1. Despite near‐complete sequence conservation of the processed FhaB segments, the SphB1 cleavage sites of FhaB from B. pertussis and B.
Jurnecka D, Man P, Sebo P, Bumba L.
europepmc   +2 more sources

SON-1010: an albumin-binding IL-12 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy [PDF]

Frontiers in Immunology
BackgroundCytokines have been promising cancer immunotherapeutics for decades, yet only two are licensed to date. Interleukin-12 (IL-12) is a potent regulator of cell-mediated immunity that activates NK cells and interferon-γ (IFNγ) production.
John K. Cini, Richard T. Kenney, Susan Dexter, Stephen J. McAndrew, Rukiye-Nazan Eraslan, Rich Brody, Darrel J. Rezac, Rebecca Boohaker, Suzanne E. Lapi, Pankaj Mohan   +9 more
doaj   +2 more sources

A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers

Frontiers in Immunology
BackgroundThe benefits of recombinant interleukin-12 (rIL-12) as a multifunctional cytokine and potential immunotherapy for cancer have been sought for decades based on its efficacy in multiple mouse models. Unexpected toxicity in the first phase 2 study
Richard T. Kenney, John K. Cini, Susan Dexter, Manuel DaFonseca, Justus Bingham, Isabelle Kuan, Sant P. Chawla, Thomas M. Polasek, Thomas M. Polasek, Jason Lickliter, Philip J. Ryan   +10 more
doaj   +1 more source

The Recruitment and Activation of Plasminogen by Bacteria-The Involvement in Chronic Infection Development. [PDF]

Int J Mol Sci, 2023
Satala D, Bednarek A, Kozik A, Rapala-Kozik M, Karkowska-Kuleta J.   +4 more
europepmc   +1 more source

Protective Efficacy of Anti-Hyr1p Monoclonal Antibody against Systemic Candidiasis Due to Multi-Drug-Resistant Candida auris. [PDF]

J Fungi (Basel), 2023
Singh S, Barbarino A, Youssef EG, Coleman D, Gebremariam T, Ibrahim AS.   +5 more
europepmc   +1 more source

Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin. [PDF]

Virulence, 2021
Arenas J, Szabo Z, van der Wal J, Maas C, Riaz T, Tønjum T, Tommassen J.   +6 more
europepmc   +1 more source

Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way. [PDF]

Microorganisms, 2021
Pompilio A, Scribano D, Sarshar M, Di Bonaventura G, Palamara AT, Ambrosi C.   +5 more
europepmc   +1 more source

Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin. [PDF]

Infect Immun, 2017
Gonyar LA, Gray MC, Christianson GJ, Mehrad B, Hewlett EL.   +4 more
europepmc   +1 more source

In vivo phosphorylation dynamics of the Bordetella pertussis virulence-controlling response regulator BvgA. [PDF]

Mol Microbiol, 2013
Boulanger A, Chen Q, Hinton DM, Stibitz S.   +3 more
europepmc   +1 more source