Results 161 to 170 of about 9,589 (207)
Some of the next articles are maybe not open access.
Trends in Molecular Medicine, 2017
Accumulation of intermediate metabolites of the tricarboxylic acid (TCA) cycle in tumor cells can cause epithelial-to-mesenchymal transition (EMT), although the exact mechanisms remain elusive. Recent studies show that the oncometabolite fumarate, which accumulates in fumarate hydratase-deficient renal cancers, confers tumor aggressiveness by causing ...
Fuhler, Gwenny +2 more
openaire +2 more sources
Accumulation of intermediate metabolites of the tricarboxylic acid (TCA) cycle in tumor cells can cause epithelial-to-mesenchymal transition (EMT), although the exact mechanisms remain elusive. Recent studies show that the oncometabolite fumarate, which accumulates in fumarate hydratase-deficient renal cancers, confers tumor aggressiveness by causing ...
Fuhler, Gwenny +2 more
openaire +2 more sources
Fumarate permeation in rat liver mitochondria: Fumarate/malate and fumarate/phosphate translocators
Biochemical and Biophysical Research Communications, 1985Fumarate permeation in isolated rat liver mitochondria was demonstrated by measuring malate and phosphate efflux caused by fumarate added externally to the mitochondrial suspension. The existence of two specific fumarate translocators, fumarate/malate and fumarate/phosphate, is shown here.
Atlante A +3 more
openaire +4 more sources
Drugs, 2003
Tenofovir disoproxil fumarate (tenofovir DF) is a prodrug of tenofovir, a nucleotide reverse transcriptase inhibitor. In two large, well designed, placebo-controlled clinical trials, tenofovir DF 300 mg/day resulted in significant reductions in HIV-1 RNA from baseline compared with placebo at 24 weeks in antiretroviral-experienced patients with HIV ...
Therese, Chapman +2 more
+7 more sources
Tenofovir disoproxil fumarate (tenofovir DF) is a prodrug of tenofovir, a nucleotide reverse transcriptase inhibitor. In two large, well designed, placebo-controlled clinical trials, tenofovir DF 300 mg/day resulted in significant reductions in HIV-1 RNA from baseline compared with placebo at 24 weeks in antiretroviral-experienced patients with HIV ...
Therese, Chapman +2 more
+7 more sources
2-Aminopyridinium–fumarate–fumaric acid (2/1/1)
Acta Crystallographica Section C Crystal Structure Communications, 2004The title complex, 2C5H7N2+.C4H2O42-.C4H4O4, contains cyclic eight-membered hydrogen-bonded rings involving 2-aminopyridinium and fumarate ions. The fumaric acid molecules and fumarate ions lie on inversion centers and are linked into zigzag chains by O-H...O hydrogen bonds.
Büyükgüngör, Orhan +3 more
openaire +2 more sources
Biochemical and Biophysical Research Communications, 1998
In order to gain some insight into the fate of fumarate synthesised in the cytosol in the purine nucleotide cycle and in amino acid catabolism, the capability of both rat kidney mitochondria and acidotic rat kidney mitochondria to take up either externally synthesised, via adenylsuccinate lyase, or added fumarate in exchange with intramitochondrial ...
ATLANTE A, GAGLIARDI S, PASSARELLA S
openaire +4 more sources
In order to gain some insight into the fate of fumarate synthesised in the cytosol in the purine nucleotide cycle and in amino acid catabolism, the capability of both rat kidney mitochondria and acidotic rat kidney mitochondria to take up either externally synthesised, via adenylsuccinate lyase, or added fumarate in exchange with intramitochondrial ...
ATLANTE A, GAGLIARDI S, PASSARELLA S
openaire +4 more sources
Triethylammonium hydrogen fumarate
Acta Crystallographica Section C Crystal Structure Communications, 2000In crystals of the title compound, the hydrogen fumarate anions form one-dimensional chains through an O-H.O hydrogen bonding along the c and (a+b)/2 directions. There are three sites of the hydrogen fumarate, two of which have an inversion centre.
Hosomi, H, Ohba, S, Ito, Y
openaire +2 more sources
Calcium monoethyl fumarate/dimethyl fumarate/magnesium monoethyl fumarate/zinc monoethyl fumarate
Reactions Weekly, 2017+6 more sources
Substrates for fumarate hydratase
Journal of the American Chemical Society, 1969Fluorofumaric acid and difluorofumaric acid are found to be substrates for fumarate hydratase. The direction of addition of water to fluorofumarate and, more importantly, the relative reactivities of fluorofumarate and difluorofumarate support a mechanism for the hydration reaction that involves a carbonium ion type intermediate.
Nigh, Wesley G., Richards, John H.
openaire +3 more sources
Lorcaserin, dimethyl fumarate, and bedaquiline fumarate
Journal of the American Pharmacists Association, 2013Daniel A, Hussar, Georgiy, Polyak
openaire +2 more sources
Nature Cell Biology, 2015
A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.
openaire +2 more sources
A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.
openaire +2 more sources