Results 241 to 250 of about 120,978 (287)
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Drugs of Today, 2010
Overactive bladder (OAB) is a common condition that causes a profound impact on an individual's overall health and quality of life. Muscarinic antagonists are the mainstay of oral pharmacotherapy for OAB. The most-recently introduced muscarinic antagonist, fesoterodine fumarate, is unique in that the parent compound has no antimuscarinic efficacy due ...
A, Gomelsky, Roger R, Dmochowski
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Overactive bladder (OAB) is a common condition that causes a profound impact on an individual's overall health and quality of life. Muscarinic antagonists are the mainstay of oral pharmacotherapy for OAB. The most-recently introduced muscarinic antagonist, fesoterodine fumarate, is unique in that the parent compound has no antimuscarinic efficacy due ...
A, Gomelsky, Roger R, Dmochowski
openaire +2 more sources
Drugs, 2003
Tenofovir disoproxil fumarate (tenofovir DF) is a prodrug of tenofovir, a nucleotide reverse transcriptase inhibitor. In two large, well designed, placebo-controlled clinical trials, tenofovir DF 300 mg/day resulted in significant reductions in HIV-1 RNA from baseline compared with placebo at 24 weeks in antiretroviral-experienced patients with HIV ...
Therese, Chapman +2 more
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Tenofovir disoproxil fumarate (tenofovir DF) is a prodrug of tenofovir, a nucleotide reverse transcriptase inhibitor. In two large, well designed, placebo-controlled clinical trials, tenofovir DF 300 mg/day resulted in significant reductions in HIV-1 RNA from baseline compared with placebo at 24 weeks in antiretroviral-experienced patients with HIV ...
Therese, Chapman +2 more
+7 more sources
2-Aminopyridinium–fumarate–fumaric acid (2/1/1)
Acta Crystallographica Section C Crystal Structure Communications, 2004The title complex, 2C5H7N2+.C4H2O42-.C4H4O4, contains cyclic eight-membered hydrogen-bonded rings involving 2-aminopyridinium and fumarate ions. The fumaric acid molecules and fumarate ions lie on inversion centers and are linked into zigzag chains by O-H...O hydrogen bonds.
Büyükgüngör, Orhan +3 more
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Fumarate permeation in rat liver mitochondria: Fumarate/malate and fumarate/phosphate translocators
Biochemical and Biophysical Research Communications, 1985Fumarate permeation in isolated rat liver mitochondria was demonstrated by measuring malate and phosphate efflux caused by fumarate added externally to the mitochondrial suspension. The existence of two specific fumarate translocators, fumarate/malate and fumarate/phosphate, is shown here.
Atlante A +3 more
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Calcium monoethyl fumarate/dimethyl fumarate/magnesium monoethyl fumarate/zinc monoethyl fumarate
Reactions Weekly, 2017+6 more sources
Triethylammonium hydrogen fumarate
Acta Crystallographica Section C Crystal Structure Communications, 2000In crystals of the title compound, the hydrogen fumarate anions form one-dimensional chains through an O-H.O hydrogen bonding along the c and (a+b)/2 directions. There are three sites of the hydrogen fumarate, two of which have an inversion centre.
Hosomi, H, Ohba, S, Ito, Y
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Clinics in Dermatology, 2008
Several clinical studies have shown that systemic therapy with fumaric acid esters (FAEs) in patients with moderate to severe psoriasis is effective and has a good long-term safety profile. For therapeutic use, tablets with a defined mixture of FAEs (dimethylfumarate [DMF] and three different salts of monoethylfumarate) are registered in Germany. There
Martin, Rostami Yazdi, Ulrich, Mrowietz
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Several clinical studies have shown that systemic therapy with fumaric acid esters (FAEs) in patients with moderate to severe psoriasis is effective and has a good long-term safety profile. For therapeutic use, tablets with a defined mixture of FAEs (dimethylfumarate [DMF] and three different salts of monoethylfumarate) are registered in Germany. There
Martin, Rostami Yazdi, Ulrich, Mrowietz
openaire +2 more sources
Trends in Molecular Medicine, 2017
Accumulation of intermediate metabolites of the tricarboxylic acid (TCA) cycle in tumor cells can cause epithelial-to-mesenchymal transition (EMT), although the exact mechanisms remain elusive. Recent studies show that the oncometabolite fumarate, which accumulates in fumarate hydratase-deficient renal cancers, confers tumor aggressiveness by causing ...
Fuhler, Gwenny +2 more
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Accumulation of intermediate metabolites of the tricarboxylic acid (TCA) cycle in tumor cells can cause epithelial-to-mesenchymal transition (EMT), although the exact mechanisms remain elusive. Recent studies show that the oncometabolite fumarate, which accumulates in fumarate hydratase-deficient renal cancers, confers tumor aggressiveness by causing ...
Fuhler, Gwenny +2 more
openaire +2 more sources
Calcium monoethyl fumarate/dimethyl fumarate/magnesium monoethyl fumarate/zinc monoethyl fumarate
Reactions Weekly, 2018openaire +2 more sources