Skeletal Muscle PGC-1α Remodels Mitochondrial Phospholipidome but Does Not Alter Energy Efficiency for ATP Synthesis. [PDF]
ABSTRACT Background The coupling of oxygen consumption to ATP synthesis via oxidative phosphorylation (OXPHOS) is central for cellular energy homeostasis. Some studies suggest exercise training increases the efficiency of ATP synthesis, but the molecular mechanisms are unclear.
Karasawa T +7 more
europepmc +2 more sources
Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle. [PDF]
Abstract Objective Glucagon‐like peptide‐1 receptor agonists (e.g., semaglutide) potently induce weight loss, thereby reducing obesity‐related complications. However, weight regain occurs when treatment is discontinued. An increase in skeletal muscle oxidative phosphorylation (OXPHOS) efficiency upon diet‐mediated weight loss has been described, which ...
Choi RH +9 more
europepmc +2 more sources
C<sub>sp</sub>, C<sub>sp</sub> <sup>2</sup>, and C<sub>sp</sub> <sup>3</sup> Hydrocarbyl Group Migration from Pd(II) to P(III): Accessing Metallophosphoranes via Nonspectator Ligand Reactivity. [PDF]
Well‐defined migration of Csp, Csp2, and Csp3 hydrocarbyls from Pd(II) compounds to a nontrigonal P(III) ligand scaffold is reported. The structural and spectroscopic features of the resulting complexes reveal a conserved Pd─P interaction. The results demonstrate the nonspectator role of structurally constrained tricoodinate P(III) ligands in palladium
Wang LU +3 more
europepmc +2 more sources
Muscle-specific Keap1 deletion enhances force production but does not prevent inactivity-induced muscle atrophy in mice. [PDF]
In absence of oxidative stress (i.e., Control, left panel) Keap1 binds and ubiquitinates the antioxidant response element (ARE) transcription factor NRF2. Ubiquitinated NRF2 is degraded and unable to act as a transcription factor for ARE‐containing genes.
Miranda ER +9 more
europepmc +2 more sources
Hypertension and obesity independently drive hypertrophy and alter mitochondrial metabolism in a mouse model of heart failure with preserved ejection fraction. [PDF]
Abstract Heart failure with preserved ejection fraction (HFpEF) has recently emerged as an insidiously and increasingly prevalent heart failure phenotype. HFpEF often occurs in the context of hypertension and obesity and presents with diastolic dysfunction, ventricular hypertrophy, and myocardial fibrosis.
Werbner B +7 more
europepmc +2 more sources
The indigenous federal Brigades program in Roraima
This article deals with the experience of indigenous brigades in Roraima, where indigenous protagonism is an important factor in the process. Until 2012, PrevFogo/IBAMA in Roraima had only one Indigenous Brigade in Pacaraima, IL São Marcos, and four ...
Inayê Uliana Perez
doaj +3 more sources
Conhecimentos A'uwe Xavante sobre manejo do fogo e políticas públicas:
Esta apresentação busca realizar um duplo relato sobre o tema do manejo do fogo nas Terras Indígenas São Marcos e Parabubure, território ocupado por mais de 10.000 indígenas da etnia Xavante, autodenominados A'uwẽ.
Eduardo Santos Gonçalves Monteiro +2 more
doaj +3 more sources
Desde a campanha presidencial de 2018, Jair Bolsonaro anunciava para diversos públicos que, se eleito, não demarcaria mais um centímetro de terra indígena. Ao iniciar seu mandato, em 2019, buscou colocar em prática uma nova relação entre o Estado e os povos indígenas, atingindo principalmente o núcleo duro da política indigenista brasileira: a Fundação
openaire +1 more source
O texto aborda a crise ambiental e seus desdobramentos, como a cultura ocidental lida com essa questão e qual seria a contribuição dos povos indígenas com relação a recuperação ambiental de seu território.
Mozart Augusto Mariano Machado
doaj +1 more source
FUNAI and INCRA PCI - reflections on Anthropology and agribusiness
Abstract Between 2015 and 2017, a Parliamentary Commission of Inquiry (PCI) took place in the Câmara dos Deputados (Brazil’s lower house) of the Brazilian National Congress, which investigated the formerly named National Indian Foundation (FUNAI) and the National Institute for Colonisation and Agrarian Reform (INCRA) in their attributions of ...
openaire +2 more sources

