Results 81 to 90 of about 27,049 (200)
Se evaluó el efectoin vitrodeLactobacillus plantarumsobreYersinia pseudotuberculosisaislada de cuyes (Cavia porcellus) e identificada bioquímica y molecularmente. Se deter-minó la viabilidad deL.
H. Jurado-Gámez +2 more
doaj
Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice
Targeting of RANKL by genetic and pharmacological approaches ameliorates key features of the progeroid phenotype in Zmpste24−/− mice. RANKL intervention restores bone mass, improves muscle phenotype, and extends survival. These findings support further exploration of RANKL‐targeted therapies for Hutchinson‐Gilford progeria syndrome.
Sandra Freitas‐Rodríguez +11 more
wiley +1 more source
RNA polymerase II phosphorylation dynamics: from molecular mechanisms to human disease
Accurate RNA polymerase II (RNAPII)–dependent gene expression requires dynamic phosphorylation of the carboxy-terminal domain (CTD) of its largest subunit, Rpb1, whose heptapeptide repeats form a regulatory platform known as the CTD code.
Araceli González-Jiménez +4 more
doaj +1 more source
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre +13 more
wiley +1 more source
Understanding the intricate pathogenic mechanisms behind Parkinson's disease (PD) and its multifactorial nature presents a significant challenge in disease modeling. To address this, we explore genetic models that better capture the disease's complexity.
Ana Perez-Villalba +7 more
doaj +1 more source
Resumen: Antecedentes y objetivo: Entre los puntos clave de una consulta monográfica de acceso vascular (AV) se encuentran una adecuada valoración preoperatoria, así como una correcta gestión y optimización de las listas de espera. El principal objetivo
Néstor Fontseré +10 more
doaj +1 more source
Abstract Bioinvasions are considered mostly as a biodiversity and conservation hazard, but in specific situations, introduced species can bring ecological or socioeconomic benefits. We assessed the social–ecological role of marine introduced species in the eastern Mediterranean Sea—a global hotspot of bioinvasions and extirpations—and their potential ...
Stelios Katsanevakis +7 more
wiley +1 more source
Objetivos Identificar os instrumentos padronizados usados para avaliar aspectos de mobilidade em crianças e adolescentes com transtorno do espectro autista (TEA), analisar a qualidade de suas propriedades psicométricas e seu nível de evidência, e desenvolver um mapa de decisão clínica para esses instrumentos.
Arthur Felipe Barroso de Lima +4 more
wiley +1 more source
El objetivo de este artículo es explicar qué efectos provoca en los estados financieros consolidados, el uso de varias y diversas divisas en la operativa de un grupo multinacional de empresas. A través de un caso práctico, basado en hechos reales, se explican y clarifican ciertos contenidos de la NIC 21 referidos a moneda de presentación, moneda ...
García Domonte, Aurora +2 more
openaire +1 more source
Land‐use change and seasonality shape the taxonomic, functional and phylogenetic diversity of fruit‐feeding butterflies in tropical dry forests. Pastures reduce phylogenetic diversity and increase wing fluctuating asymmetry, while taxonomic and functional diversity is greater in the wet season than in the dry season.
João Rafael S. Macêdo +8 more
wiley +1 more source

