Results 101 to 110 of about 857,366 (269)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A Study of Brain Function Characteristics of Service Members at High Risk for Accidents in the Military. [PDF]

Brain Sci, 2023
Choi SO, Choi JG, Yun JY.
europepmc   +1 more source

Serverless Computing & Function-as-a-Service (FaaS) Optimization

The American Journal of Engineering and Technology, 2023
Function-as-a-Service (FaaS) in cloud computing is a critical optimization problem that needs to be tackled, including cold start latency, resource inefficiency, state management, and more. While FaaS provides obvious scalability and lower cost benefits, the lack of availability of resources and the problem of cold starts to prevent it from being used ...
openaire   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Improved grey wolf optimization algorithm based service function chain mapping algorithm

Dianxin kexue, 2022
With the rise of new Internet applications such as the industrial Internet, the Internet of vehicles, and the metaverse, the network’s requirements for low latency, reliability, security, and certainty are facing severe challenges.In the process of ...
Yue ZHANG, Junnan ZHANG, Xiaochun WU, Chen HONG, Jingjing ZHOU   +4 more
doaj   +2 more sources

A Conceptual Framework to Integrate Biodiversity, Ecosystem Function, and Ecosystem Service Models. [PDF]

Bioscience, 2022
Weiskopf SR, Myers BJE, Arce-Plata MI, Blanchard JL, Ferrier S, Fulton EA, Harfoot M, Isbell F, Johnson JA, Mori AS, Weng E, HarmáCˇková ZV, Londoño-Murcia MC, Miller BW, Pereira LM, Rosa IMD.   +15 more
europepmc   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

SAFE—A Scalable and Agile Framework for Mixed Critical Event Detection

IEEE Access
Real-time video stream processing is challenging for detection of mixed critical events. Challenges lie in developing a scalable platform that not only detects multiple events according to their criticality but can also meet multi-tenancy requirements ...
Mukand Krishna, Jawwad Ahmed Shamsi, Muhammad Burhan Khan, Narmeen Zakaria Bawany, Hassan Jamil Syed   +4 more
doaj   +1 more source

Depression symptoms as a potential mediator of the association between disordered eating symptoms and sexual function in women service members and veterans. [PDF]

Mil Psychol, 2022
Livingston WS, Fargo JD, Blais RK.
europepmc   +1 more source