Results 231 to 240 of about 10,460,134 (315)

Examining bidirectional longitudinal relationships between physical activity and physical function in older breast cancer survivors: The Thinking and Living with Cancer study. [PDF]

Cancer
Artese AL, Zhou X, Small BJ, Ahles TA, Ahn J, Bethea TN, Casagrande CC, Choi E, Cohen HJ, Extermann M, Graham D, Hall K, Isaacs C, Jim HSL, Kusters CDJ, McDonald BC, Nakamura ZM, Patel SK, Rentscher KE, Root JC, Saykin AJ, Van Dyk K, Zhai W, Carroll JE, Mandelblatt J.   +24 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Effects of Aging on Correlation of Striated Esophageal and Pharyngeal Deglutitive Motor Function. [PDF]

Gastroenterol Res Pract
Kern M, Edeani F, Mei L, Sanvanson P, Shaker R.   +4 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Addressing Key Limitations of Diastolic Function Assessment in Mouse Echocardiography by Enabling Robust Retrospective Analysis From a Standard Imaging View. [PDF]

Acta Physiol (Oxf)
Marterstock M, Schauer A, Maslakova A, Opitz A, Dieterich P, Speier S, Kämmerer S, Mirtschink P, Kopaliani I, Deussen A.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Anti-apoptotic and anti-glycative effects of asiatic acid in brain of d-galactose treated mice

, 2015
Chao；殷梅津, Pei-chun Cha；Pei-chun, Chao), Pei-chun Cha(Pei-chun;殷梅津;Mong), 蒙美津(Mei-Shin, Cha, Pei-chun;Chao, Pei-chun;殷梅津*;蒙美津;Mong, Mei-Shin, Cha, Pei-chun;Chao, Pei-chun;蒙美津, 殷梅津 ;Mong, Mei-Shin, Cha, Pei-chun;Chao, Pei-chun;殷梅津;蒙美津;Mong, Mei-Shin, Chao), Pei-chun Cha(Pei-chun;殷梅津*;Mong), 蒙美津(Mei-Shin   +5 more
core  

Carbonic anhydrase VIII as a regulator of intracellular calcium signaling: mechanistic insights and implications in human disease. [PDF]

Mol Biol Rep
Aspatwar A.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source