Results 11 to 20 of about 46,686 (188)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The harmonic oscillator on Riemannian and Lorentzian configuration spaces of constant curvature
, 2007 The harmonic oscillator as a distinguished dynamical system can be defined not only on the Euclidean plane but also on the sphere and on the hyperbolic plane, and more generally on any configuration space with constant curvature and with a metric of any ...
Coolidge J. L. +12 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Approach of the Generating Functions to the Coherent States for Some Quantum Solvable Models [PDF]
, 2014 We introduce to this paper new kinds of coherent states for some quantum solvable models: a free particle on a sphere, one-dimensional Calogero-Sutherland model, the motion of spinless electrons subjected to a perpendicular magnetic field B, respectively,
Dehghani, A., Mojaveri, B.
core
Genetic Exponentially Fitted Method for Solving Multi-dimensional Drift-diffusion Equations
, 2013 A general approach was proposed in this article to develop high-order exponentially fitted basis functions for finite element approximations of multi-dimensional drift-diffusion equations for modeling biomolecular electrodiffusion processes. Such methods
Swager, Melissa R., Zhou, Y. C.
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
Comparison moduli spaces of Riemann surfaces
, 2017 We define a kind of moduli space of nested surfaces and mappings, which we call a comparison moduli space. We review examples of such spaces in geometric function theory and modern Teichmueller theory, and illustrate how a wide range of phenomena in ...
Schippers, Eric, Staubach, Wolfgang
core +1 more source