Results 201 to 210 of about 3,444,674 (308)

Correction: A novel LACC1 variant c.658G > A (p.Asp220Asn) in familial juvenile arthritis: identification and functional analysis. [PDF]

Hum Genomics
Alblooshi H, Mustafa N, Khalam AA, Bharathan A, Mohammed E, Baydoun I, Tabouni M, Allam M, Almansoori M, Fatima T, Aljaberi N.   +10 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Functional analysis of the FGF2 gene in horn development in sheep and identification of key regulatory variants. [PDF]

BMC Genomics
Liu F, Li H, Meng Z, Zhang S, Yang H, Hu Y, Ciwang R, He J, Pan Z.   +8 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Functional analysis of human EED variants using Drosophila. [PDF]

Genetics
Cyrus SS, Medina-Giró S, Lian T, Allan DW, Gibson WT.   +4 more
europepmc   +1 more source

Development of a Stem-color Mutant Kenaf (Hibiscus cannabinus L.) Cultivar, ‘Jeokbong’, and Analysis of its Functional Compounds

, 2018
Jaihyunk Ryu, Soon‐Jae Kwon, Joon‐Woo Ahn, Sang Hoon Kim, Seung Young Lee, Jin-Back Kim, YeongDeuk Jo, Bo‐Keun Ha, Si‐Yong Kang   +8 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Systematic structural and functional analysis of metal-binding sites in native proteomes

Quast J, Pagotto A, Separovich R, Dünnebacke M, Gillet L, Luo X, Züger E, Magnusson G, Correia M, Ciofalo C, Andreini C, Rosato A, Beltrao P, Zamboni N, de Souza N, Picotti P.   +15 more
europepmc   +1 more source

Structural and Functional Analysis of ASFV pI73R Reveals GNB1 Binding and Host Gene Modulation. [PDF]

Int J Mol Sci
Dolata KM, Bettin B, Küchler R, Pannhorst K, Ushakov DS, Fuchs W, Karger A.   +6 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source