Results 251 to 260 of about 8,080,966 (340)

Stiff-FCS: Single-Cell Stiffness Profiling With Integrated Molecular and Functional Analysis

Yuhao Zhang, Luyao Zhao, Zhengfu Huang, Kenan Song, Xianqiao Wang, Xianyan Chen, Jin Xie, Yiping Zhao, He Li, Leidong Mao, Yong Teng, Yang Liu   +11 more
openalex   +2 more sources

Functional analysis of a Drosophila melanogaster olfactory receptor expressed in Sf9 cells

, 2006
Aidan Kiely, Astrid Authier, Andrew V. Kralicek, Coral G. Warr, Richard D. Newcomb   +4 more
openalex   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Functional analysis of NPR2 variants supports the therapeutic rationale for CNP in short stature. [PDF]

Am J Hum Genet
Jeong R, Covarrubias S, Shanghavi D, Ruhrmund D, Estrada K, Zhou D, Marom N, Bauer CR, Froelich S.   +8 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Screening and molecular functional analysis of telomere-related genes in abdominal aortic aneurysms based on bioinformatics. [PDF]

Front Cardiovasc Med
Yuan T, Bi W, Liu Y, Sun H, Cui N, Wang J, Hou J, Song R, Gao X.   +8 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Plant Non-Specific Lipid Transfer Proteins (nsLTPs): Comprehensive Functional Analysis and Defense Mechanisms. [PDF]

Biology (Basel)
Giri B, Kumar D.
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source