Results 311 to 320 of about 557,186 (345)
Some of the next articles are maybe not open access.
Annotated functional decomposition
Computer Applications in Engineering Education, 2021AbstractExperiences gained from the domain‐specific courses showed that students focus mostly on how to implement solutions and less on what must be considered within the solution. In the case of information systems‐related courses, students focus on system development using specific languages and frameworks while often disregard the required logical ...
Stefan Tubić +3 more
openaire +1 more source
Functional Annotation of Custom Transcriptomes
2022Many eukaryotic genes can give rise to different alternative transcripts depending on stage of development, cell type, and physiological cues. Current transcriptome-wide sequencing technologies highlight the remarkable extent of this regulation in metazoans and allow for RNA isoforms to be profiled in increasingly small biological samples and with a ...
Fursham Hamid +3 more
openaire +2 more sources
Functional Annotation from Structural Homology
2021With the nexus of super computing and the biotech revolution, it seems an era of predictive biology through systems biology may be at hand. Modern omics capabilities enable examination of the state of biological system in exquisite detail. The genome, transcriptome, proteome, and metabolome may all be largely knowable, at least for some model systems ...
openaire +2 more sources
2019
The deluge of sequencing data needs curated association of structural and functional features to each sequence in the database. Inference of correct annotation is a major problem of sequence analysis. We highlight why it is difficult to solve the annotation task given the little amount of validated information in the database linking sequences ...
Pier Luigi Martelli +2 more
openaire +2 more sources
The deluge of sequencing data needs curated association of structural and functional features to each sequence in the database. Inference of correct annotation is a major problem of sequence analysis. We highlight why it is difficult to solve the annotation task given the little amount of validated information in the database linking sequences ...
Pier Luigi Martelli +2 more
openaire +2 more sources
Protein Functional Annotation by Homology
2008Genome sequencing projects have resulted in a rapid accumulation of predicted protein sequences. With experimentally verified information on protein function lagging far behind, computational methods are used for functional annotation of proteins. Here we describe a number of protocols for protein sequence and structure analysis that can be used to ...
Raja, Mazumder +2 more
openaire +2 more sources
Automatic annotation of protein function
Current Opinion in Structural Biology, 2005The annotation of protein function at genomic scale is essential for day-to-day work in biology and for any systematic approach to the modeling of biological systems. Currently, functional annotation is essentially based on the expansion of the relatively small number of experimentally determined functions to large collections of proteins.
openaire +2 more sources
Functional genome annotation through phylogenomic mapping
Nature Biotechnology, 2005Accurate determination of functional interactions among proteins at the genome level remains a challenge for genomic research. Here we introduce a genome-scale approach to functional protein annotation--phylogenomic mapping--that requires only sequence data, can be applied equally well to both finished and unfinished genomes, and can be extended beyond
Balaji S, Srinivasan +8 more
openaire +2 more sources
Resources for functional annotation
2008The continued success of genome sequencing projects has led to an explosion in the availability of sequence data. The Genomes On Line Database (GOLD) currently lists more than 2000 ongoing and completed genome projects, and this number is continuously increasing (Liolios et al. 2008).
A. J. Bridge +2 more
openaire +1 more source
Manual Gene Curation and Functional Annotation
2018No genome sequencing project is complete without structural and functional annotation. Gene models and functional predictions for these models can be obtained relatively easily using computational methods, but they are prone to errors. We describe herein the steps we use to manually curate gene models and functionally annotate them.
McDonnell, Erin +2 more
openaire +2 more sources
Variant Annotation and Functional Prediction: SnpEff
2012Variant annotations, in general, refer to the process of information enrichment of genomic variants from a sequencing experiment. Typically these annotations include functional predictions, such as predicting the amino acid sequence changes from the DNA variant, predicting whether the variant will induce a splice anomaly, or predicting nonsense ...
openaire +2 more sources