Results 131 to 140 of about 2,947,952 (242)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Electropolymerization of 5-Indolylboronic Acid: Morphological, Spectroscopic, and Electrochemical Characterization with Perspective Toward Functional Applications. [PDF]

Polymers (Basel)
Ramos D, Aguirre MJ, Armijo F.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Recent Progress in Photoresponsive Room-Temperature Phosphorescent Materials: From Mechanistic Insights to Functional Applications. [PDF]

Molecules
Chen Y, Huang Y, Zeng Z, Luo G.
europepmc   +1 more source

Anew Synthetic Polymers Based on Polyaniline for Dual-Functional Applications: Photoelectrochemical Water Splitting and Antibacterial Activities. [PDF]

ACS Omega, 2021
Abdelfattah RM, Shaban M, Mohamed F, El-Reedy AAM, Abd El-Salam HM.   +4 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Next-generation cobalt hybrid material: structural, luminescence, and dielectric properties for advanced functional applications. [PDF]

RSC Adv
Khachroum H, Rhaiem AB, Abdelbaky MSM, García-Granda S, Dammak M.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Diversity of Bioactive Compounds in Microalgae: Key Classes and Functional Applications. [PDF]

Mar Drugs
Osathanunkul M, Thanaporn S, Karapetsi L, Nteve GM, Pratsinakis E, Stefanidou E, Lagiotis G, Avramidou E, Zorxzobokou L, Tsintzou G, Athanasiou A, Mpelai S, Constandinidis C, Pantiora P, Merino M, Mullor JL, Dobrovic L, Cerasino L, Ogawa T, Tsaousi M, Rodrigues AMC, Cardoso H, Pires R, Figueiredo D, Costa IF, Anjos C, Labrou NE, Madesis P.   +27 more
europepmc   +1 more source

LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications. [PDF]

Antioxidants (Basel), 2021
Sinan KI, Akpulat U, Aldahish AA, Celik Altunoglu Y, Baloğlu MC, Zheleva-Dimitrova D, Gevrenova R, Lobine D, Mahomoodally MF, Etienne OK, Zengin G, Mahmud S, Capasso R.   +12 more
europepmc   +1 more source