Results 41 to 50 of about 2,947,952 (242)

Compressed Static Functions with Applications [PDF]

Proceedings of the Twenty-Fourth Annual ACM-SIAM Symposium on Discrete Algorithms, 2013
Given a set of integer keys from a bounded universe along with associated data, the dictionary problem asks to answer two queries: membership and retrieval. Membership has to tell whether a given element is in the dictionary or not; Retrieval has to return the data associated with the searched key.
Belazzougui Djamal, VENTURINI, ROSSANO
openaire   +4 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Functional Regression [PDF]

, 2014
Functional data analysis (FDA) involves the analysis of data whose ideal units of observation are functions defined on some continuous domain, and the observed data consist of a sample of functions taken from some population, sampled on a discrete grid ...
Morris, Jeffrey S.
core  

Blockchain-based Data Provenance for the Internet of Things

, 2019
As more and more applications and services depend on data collected and provided by Internet of Things (IoT) devices, it is of importance that such data can be trusted.
Bertino E., Eberhardt J., Polyzos G. C., Ramachandran A., Simmhan Y. L., Westerkamp M.   +5 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Seeking for reliable double-hybrid density functionals without fitting parameters: The PBE0-2 functional

, 2012
Without the use of any empirical fitting to experimental or high-level ab initio data, we present a double-hybrid density functional approximation for the exchange-correlation energy, combining the exact Hartree-Fock exchange and second-order Moller ...
Adamo, Bally, Becke, Boys, Brémond, Burns, Chai, Chai, Chai, Chai, Cohen, Curtiss, Curtiss, Curtiss, Dion, Dirac, Dobson, Grimme, Grimme, Grimme, Grimme, Grimme, Jeng-Da Chai, Jurečka, Kendall, Kohn, Kurlancheek, Mller, Perdew, Perdew, Perdew, Perdew, Pople, Raghavachari, Redfern, Rezac, Shan-Ping Mao, Shao, Sharkas, Song, Steinmann, Stephens, Takatani, Tao, Toulouse, Wodrich, Zhang, Zhao, Zhao, Zhao, Zhao   +50 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Exponential functionals of Levy processes

, 2005
This text surveys properties and applications of the exponential functional $\int_0^t\exp(-\xi_s)ds$ of real-valued L\'evy processes $\xi=(\xi_t,t\geq0)$.Comment: Published at http://dx.doi.org/10.1214/154957805100000122 in the Probability Surveys ...
Bertoin, Jean, Yor, Marc
core   +1 more source