Results 101 to 110 of about 3,034,015 (300)

RESPONSE TO 6 MINUTE WALK TEST IN HEALTHY ADULTS

International Journal of Physiotherapy, 2015
Background: 6Minute walk test (MWT) has been used as a performance based measure of functional exercise capacity in all populations including healthy adults.
Vibhuti kiran shah, Mugdha Oberoi, Veena krishnanand   +2 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

PHYSICAL ACTIVITY, FUNCTIONAL CAPACITY AND QUALITY OF LIFE IN OLDER PEOPLE [PDF]

, 2008
Gerontological research has shown that there is a marked decline in health with age and an associated demand for expensive medical services (Shepard, 1993).
Bravo, Jorge, FOLGADO, HUGO, RAIMUNDO, ARMANDO, TOMÁS-CARUS, PABLO   +3 more
core  

A Minimal Set of Shannon-type Inequalities for Functional Dependence Structures

, 2017
The minimal set of Shannon-type inequalities (referred to as elemental inequalities), plays a central role in determining whether a given inequality is Shannon-type. Often, there arises a situation where one needs to check whether a given inequality is a
Chan, Terence, Grant, Alex, Thakor, Satyajit   +2 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Six-Minute Walk Test among obese and nonobese subjects: A comparative analysis among apparently healthy volunteers

Annals of Medical Science and Research
Context: The Six-Minute Walk Test (6MWT) is a simple measure for objective assessment of physical fitness and exercise tolerance. It has also been standardized to follow up on the prognosis and progression of chronic cardiovascular and respiratory ...
Tandra Ghosh, Manjusha Ashlesh Shinde, Suchita Narayan Kawale, Shiv Kumar, Aparajita Sophia D’Souza   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effect of Exercise Programs on Physical Performance in Community-Dwelling Older Adults with and without Frailty: Systematic Review and Meta-Analysis

Geriatrics
Background: The measurement of physical performance constitutes an indicator of the physical functional capacity of older adults with and without frailty. Aim: To present a synthesis of knowledge on the effect of exercise programs on physical performance
Cristina Flores-Bello, Elsa Correa-Muñoz, Martha A. Sánchez-Rodríguez, Víctor Manuel Mendoza-Núñez   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source