Results 161 to 170 of about 3,034,015 (300)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

The effect of cardiac resynchronization therapy on functional capacity based on cardiopulmonary exercise testing: a systematic review and meta-analysis. [PDF]

Eur Heart J Open
Solano J, Rahunathan N, Sykes DL, Eni G, Edhem L, Witte KK.   +5 more
europepmc   +1 more source

Functional Residual Capacity [PDF]

, 2020
openaire   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

New Fuels for a Failing Engine: The Impact of Novel Heart Failure Drugs on Functional Capacity. [PDF]

Rev Cardiovasc Med
Baracchini N, Capovilla TM, Costantino S, Puttini F, Salvioni E, Mattavelli I, Valenti M, d'Elia E, Bertarelli E, Agostoni P, Sinagra G, Mapelli M.   +11 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Pulmonary rehabilitation efficacy on quality of life and functional capacity in interstitial lung disease. [PDF]

Bioinformation
H Albitar M, G G, Andanappa A, Kukunoor HR, Kc G, Garapati A, Shaik AT, Rana F, Ali M, Mateen MA.   +9 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Validation of the virtual reality functional capacity assessment tool (VRFCAT) in a Spanish sample of individuals with psychosis and healthy controls. [PDF]

Eur Psychiatry
González-Blanch C, López-Carrilero R, Bobes-Bascarán T, Catalán A, Aymerich C, Rodriguez-Jimenez R, Gutiérrez-Zotes A, Díaz-Mandado O, González-Pinto A, Cano-Escalera G, Zubia M, Guinart D, Del-Castillo-Serrano M, Vilella E, García-Álvarez L, Ochoa S, Correa-Ghisays P, Balanzá-Martínez V, Sánchez-Ortí JV, Pousa E, Miret S, Falip C, Reguera-Pozuelo P, Fernández-Martínez R, García-Cabeza I, Campos-Rodriguez C, Crosas JM, Cobo J, Pardina-Torner H, Perona-Garcelán S, Muñoz-Caracuel M, Yorca-Ruiz Á, Ortiz-García de la Foz V, Ayesa-Arriola R.   +33 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source