Results 61 to 70 of about 838,497 (309)

Regional functional classification results.

, 2021
Regional functional classification results.
Ulrike Kuhl (11507258), Sarah Sobotta (11507261), Michael A. Skeide (9553046)   +2 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Discriminative Validity of Field-Based Propulsion and Sprint Tests in Elite Wheelchair Court Athletes with Different Functional Profiles

Sports
Purpose: Field-based tests are widely used to assess propulsion and sprint performance in wheelchair athletes; however, their ability to discriminate between functional performance profiles associated with different impairment characteristics remains ...
Jordi Sanchez-Grau, Roger Font, Víctor Toro-Román, Gerard Carmona, Adrián García-Fresneda   +4 more
doaj   +1 more source

Safe Functional Inference for Uncharacterized Viral Proteins

, 2008
The explosive growth in the number of sequenced genomes has created a flood of protein sequences with unknown structure and function. A routine protocol for functional inference on an input query sequence is based on a database search for homologues ...
Yaniv Loewenstein, Michal Linial
core   +2 more sources

Gene ontology functional classification.

, 2022
Gene ontology functional classification.
Pavol Hlaváč (12066055), M. Ajmal Ali (12066058), Muhmmad Rizwan (12066052), Songkun Su (48025), Muhammad Fahad Raza (12066049), Arif Husain (6286937), Hongyi Nie (549438), Muhammad Anwar (4014383), Ahmed Rady (8073326), Zhiguo Li (431917)   +9 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Functional profiling of LDLR variants: Important evidence for variant classification: Functional profiling of LDLR variants

, 2022
Background: Familial Hypercholesterolemia (FH) is a semidominant disorder of the lipid metabolism associated with premature atherosclerosis and coronary heart disease.
Zimon, Magdalena, Pepperkok, Rainer, Bourbon, Mafalda, Graça, Rafael, Alves, Ana Catarina   +4 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Cross-Cultural Adaptation and Validation of the Mini-Eating and Drinking Ability Classification System for Korean Children with Cerebral Palsy Aged 18–36 Months

Children
Background/Objectives: Feeding and swallowing difficulties are common in young children with cerebral palsy (CP), yet no validated tool has been available in Korea for those under 3 years.
You Gyoung Yi, Seoyon Yang, Jeong-Yi Kwon, Dong-wook Rha, Juntaek Hong, Ja Young Choi, Eun Jae Ko, Bo Young Hong, Dae-Hyun Jang   +8 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source