Results 51 to 60 of about 838,497 (309)

Re-purposing software for functional characterization of the microbiome

Microbiome, 2021
Background Widespread bioinformatic resource development generates a constantly evolving and abundant landscape of workflows and software. For analysis of the microbiome, workflows typically begin with taxonomic classification of the microorganisms that ...
Laura-Jayne Gardiner, Niina Haiminen, Filippo Utro, Laxmi Parida, Ed Seabolt, Ritesh Krishna, James H. Kaufman   +6 more
doaj   +1 more source

A Structural and Functional Acromegaly Classification [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2015
GH-secreting pituitary adenomas exhibit heterogeneous natural history ranging from small tumors to large aggressive adenomas.To rigorously classify an acromegaly patient cohort defined by clinical, radiological, histopathological, and outcome characteristics.Cross-sectional study.Tertiary referral pituitary center.Subjects were selected from a ...
Daniel, Cuevas-Ramos, John D, Carmichael, Odelia, Cooper, Vivien S, Bonert, Arkadiusz, Gertych, Adam N, Mamelak, Shlomo, Melmed   +6 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Excipients in biological medicinal products: Functional classification, stability issues, and analytical quantitation approaches

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. When developing and evaluating new biological products (BP), potential adverse action and complicated analytical procedure are a specific issue.
A. S. Minero, O. B. Rounova, I. M. Shcherbachenko, O. B. Ustinnikova   +3 more
doaj   +1 more source

GPCRTree: online hierarchical classification of GPCR function [PDF]

, 2008
Background: G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR.
Davies Matthew N, Clark, Edward, Halling-Brown Mark, Flower Darren R, Moss, David S., Alex A Freitas, Halling-Brown, Mark D., Clark, E., Timmis Jon, Flower, Darren R, Andrew Secker, Freitas, Alex A., Timmis, J., Davies, M.N., David S Moss, Secker, Andrew D., Secker, A., Halling-Brown, Mark, Moss David S, Timmis, Jon, Freitas, A.A., Mark Halling-Brown, Clark Edward, Secker Andrew, Secker, Andrew, Flower, Darren R., Jon Timmis, Edward Clark, Matthew N Davies, Freitas Alex A, Davies, Matthew N., Darren R Flower, Flower, D.R.   +32 more
core   +1 more source

Functional classification of COG.

, 2022
Functional classification of COG.
Zhijun Zhao (784822), Suna Han (4808055), Junying Fu (5721752), Linlin Wang (289071), Chunmei Pan (9958556), Yanbo Liu (180774), Huihui Wang (442901), Xiyu Sun (6637469)   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Competitive level differences in basic motor skills of wheelchair basketball players: a cross- sectional observational study

Frontiers in Physiology
IntroductionPerformance in wheelchair basketball largely depends on athletes’ physical performance, particularly basic motor abilities required for efficient wheelchair propulsion and movement during play. This study aimed to examine differences in basic
Miljan Hadžović, Miljan Hadžović, Miljan Hadžović, Stefan Stojanović, Tamara Ilić, Ana Lilić, Ismail Ilbak, Marko Aleksandrović, Marko Aleksandrović, Marko Aleksandrović, Zhencheng Li   +10 more
doaj   +1 more source

Classification of autism spectrum disorder using supervised learning of brain connectivity measures extracted from synchrostates

, 2014
Objective. The paper investigates the presence of autism using the functional brain connectivity measures derived from electro-encephalogram (EEG) of children during face perception tasks. Approach.
Oprescu, Ioana-Anastasia, Das, Saptarshi, Maharatna, Koushik, Sicca, Federico, Jamal, Wasifa, Apicella, Fabio   +5 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source