Results 111 to 120 of about 838,497 (309)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Curve Data Classification via Functional Regression Analysis

, 2012
計畫編號：NSC100-2118-M032-006研究期間：20110801~20120731研究經費：315,000本計畫將討論曲線資料(curve data)的分類(classification)問題，尤其是當存 在有與分類相關的解釋變數(covariates)時，探討如何將這些解釋變數有用之訊 息有效加入函數型分類方法中。我們將曲線資料視為隨機過程的實際觀測值， 並假設在多個已知分類下，各類隨機函數的平均函數與共變異函數均可能相 異。在給定相關解釋變數的訊息下，我們將利用條件函數型主成份分析 ...
李百靈
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

KOG functional classification.

, 2015
KOG functional classification.
Ran Tang (175386), YuMei Chang (758583), XuLing He (758584), LiQun Liang (758582)   +3 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Classification with Sums of Separable Functions [PDF]

, 2010
We present a novel approach for classification using a discretised function representation which is independent of the data locations. We construct the classifier as a sum of separable functions, extending the paradigm of separated representations. Such a representation can also be viewed as a low rank tensor product approximation. The central learning
openaire   +1 more source

Multiclass Classification Calibration Functions

CoRR, 2016
44 ...
Bernardo Ávila Pires, Csaba Szepesvári
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

DNA binding proteins: outline of functional classification

Biomolecular Concepts, 2011
DNA-binding proteins composed of DNA-binding domains directly affect genomic functions, mainly by performing transcription, DNA replication or DNA repair.
Zheng Zhiming, Wang Ya
doaj   +1 more source

Morphology-based classification of functional groups for potamoplankton

Journal of Limnology, 2015
Simple morphological traits of phytoplankton have proven to correlate well with the functional properties of taxa. A logical way of distinguishing functional groups of phytoplankton is to cluster species according to their morphological traits, instead ...
Ning Chen, Ling Liu, Yanfeng Li, Danying Qiao, Yuanpo Li, Ying Zhang, Yiyan Lv   +6 more
doaj   +1 more source