Results 71 to 80 of about 5,057,856 (264)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Re-purposing software for functional characterization of the microbiome
Microbiome, 2021 Background Widespread bioinformatic resource development generates a constantly evolving and abundant landscape of workflows and software. For analysis of the microbiome, workflows typically begin with taxonomic classification of the microorganisms that ...
Laura-Jayne Gardiner +6 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Translational Exercise BiomedicineRegular physical activity is essential for healthy growth, cardiometabolic health, musculoskeletal development and psychosocial well-being in children and adolescents.
Rozenstoka Sandra +9 more
doaj +1 more source
COG functional classification of DEGs.
, 2014 COG functional classification of DEGs.
Dongmei Tan (160346) +7 more
core +1 more source
Functional classification of secondary lymphedema
Annals of Medicine and Surgery, 2019 The epidemiological classifications of primary lymphedema based on age at emergence and the severity of the edema are fundamental to the transmission of information about this condition. In the secondary type, the lymphatic system is intact at birth but is injured during the course of life, causing a deficiency that leads to lymphedema.
Jose Maria Pereira de Godoy +1 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Frontiers in PhysiologyIntroductionPerformance in wheelchair basketball largely depends on athletes’ physical performance, particularly basic motor abilities required for efficient wheelchair propulsion and movement during play. This study aimed to examine differences in basic
Miljan Hadžović +10 more
doaj +1 more source