Results 91 to 100 of about 6,020,045 (311)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Functional classification systems and their association with botulinum toxin type a use in pediatric cerebral palsy

Scientific Reports
Botulinum toxin type A (BoNT-A) is a key intervention for the management of spasticity in children with cerebral palsy (CP); however, the functional factors associated with its use remain incompletely defined.
Duygu Kurtuluş, Gokhan Basar, Ozlem Kaleoglu   +2 more
doaj   +1 more source

Functional classification and gene enrichment analysis.

, 2016
Functional classification and gene enrichment analysis.
Debora Olioso (3342434), Clara Bonafini (3342428), Elisabetta Galbiati (1618450), Anna Baruzzi (236507), Laura Bettinetti (1451140), Francesca Di Leva (269600), Paolo Bellavite (12522), Marta Marzotto (3342431)   +7 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Relationship between functional capacity and socioeconomic status in a cohort of Turkish heart failure patients

Türk Kardiyoloji Derneği Arşivi, 2016
Objective: New York Heart Association (NYHA) classification predicts prognosis for heart failure (HF) patients. Socioeconomic status (SES) has the potential to affect treatment strategy and disease course.
Hakkı Kaya, Meltem Refiker Ege, Ali Zorlu, Osman Beton, Hasan Güngör, Ahmet Temizhan, Yeşim Güray, Yüksel Çavuşoğlu, Mehdi Zoghi, Mehmet Birhan Yılmaz, On Behalf Of TREAT-HF Investigators   +10 more
doaj   +1 more source

Medicare functional classification levels (K-levels).

, 2013
Medicare functional classification levels (K-levels).
Mark V. Albert (323769), Arun Jayaraman (323771), Megan Herrmann (323770), Konrad Kording (141310), Juliana Valentin (418177), Cliodhna McCarthy (418176)   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Long-Term Outcome after Pneumonectomy at Siriraj Hospital

Siriraj Medical Journal, 2020
Objective: The purpose of this study is to identify predictors of long term survival following pneumonectomy and compare New York Heart Association (NYHA) functional classification and ECOG performance status before and after surgery at Siriraj Hospital.
Wanchai Wongkornrat, Somchai Sriyoscharti, Teeravit Phanchaipetch, Thaworn Subtaweesin, Punnarerk Thongchareon, Pranya Sakiyalak, Worawong Slisatkorn, Akarin Nimmannit, Pansak Laksanabunsong   +8 more
doaj  

A functional classification of metropolitan communities [PDF]

Demography, 1973
Abstract Five major approaches to the functional classification of communities have been offered. Although most of them allow the recognition of a community as specialized in more than one function, their application necessitates consideration of the several individual functions one at a time.
openaire   +2 more sources