Results 71 to 80 of about 6,020,045 (311)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Automatic classification of citation function [PDF]

Proceedings of the 2006 Conference on Empirical Methods in Natural Language Processing - EMNLP '06, 2006
Citation function is defined as the author's reason for citing a given paper (e.g. acknowledgement of the use of the cited method). The automatic recognition of the rhetorical function of citations in scientific text has many applications, from improvement of impact factor calculations to text summarisation and more informative citation indexers.
Simone Teufel, Advaith Siddharthan, Dan Tidhar   +2 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A functional-condition-based expert framework for safe participation in school physical education among children with health conditions

Translational Exercise Biomedicine
Regular physical activity is essential for healthy growth, cardiometabolic health, musculoskeletal development and psychosocial well-being in children and adolescents.
Rozenstoka Sandra, Atava-Cudare Endija, Bondins Jevgenijs, Kozlovska Liga, Silova Alla, Aispure Aiva, Dekmeijere-Trigubova Laila, Gobina Sarmite, Mickus Matiss, Savko Regina   +9 more
doaj   +1 more source

COG functional classification of DEGs.

, 2014
COG functional classification of DEGs.
Dongmei Tan (160346), Yun Wei (245421), Guohui Huang (628934), Zhongyu Jiang (628936), Aide Wang (628938), Xinyue Li (628935), Tong Li (206968), Juncai Li (628937)   +7 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Competitive level differences in basic motor skills of wheelchair basketball players: a cross- sectional observational study

Frontiers in Physiology
IntroductionPerformance in wheelchair basketball largely depends on athletes’ physical performance, particularly basic motor abilities required for efficient wheelchair propulsion and movement during play. This study aimed to examine differences in basic
Miljan Hadžović, Miljan Hadžović, Miljan Hadžović, Stefan Stojanović, Tamara Ilić, Ana Lilić, Ismail Ilbak, Marko Aleksandrović, Marko Aleksandrović, Marko Aleksandrović, Zhencheng Li   +10 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

How do Government Expenditures by Function Affect Economic Growth? Evidence from Indonesia

Ekuilibrium: Jurnal Ilmiah Bidan Ilmu Ekonomi
This study addresses a key gap in the empirical literature on fiscal policy and economic growth: while numerous studies assess the impact of total government spending, few examine the differential effects of expenditures by function under the COFOG ...
Rido Parulian Panjaitan, Renny Sukmono, Muhammad Syahrul Fuady, Nurfiryal Salsabila, Farhan Hadiantoro   +4 more
doaj   +1 more source