Results 111 to 120 of about 5,057,856 (264)

Functional classification of conserved maize miRNA targets.

open access: yes, 2015
Functional classification of conserved maize miRNA targets.
Weihua Li (144468)   +6 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Functional classification of transcripts from all clusters.

open access: yes, 2013
Functional classification of transcripts from all clusters.
Felipe A. A. Oliveira (409531)   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

ATRIAL FIBRILLATION: FUNCTIONAL CLASSIFICATION

open access: yesВестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2020
In article, we studied the heart biomechanics and main arteries kinetics in different types of atrial fibrillation. We described the increase of main hemodynamic parameters in atrial fibrillation.
A. V. Germanov   +3 more
doaj  

Functional classification of the identified proteins.

open access: yes, 2015
Functional classification of the identified proteins.
Yunqiang Yang (571230)   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Functional classification of DEGs in differentiating spikes.

open access: yes, 2016
Functional classification of DEGs in differentiating spikes.
Yu-Mei Jiang (3178533)   +7 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Summary of functional classification of SVs identified.

open access: yes, 2018
Summary of functional classification of SVs identified.
Sheng Li (107261)   +4 more
core   +1 more source

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