Results 91 to 100 of about 5,609,232 (306)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional profiling of LDLR variants: Important evidence for variant classification: Functional profiling of LDLR variants

, 2022
Background: Familial Hypercholesterolemia (FH) is a semidominant disorder of the lipid metabolism associated with premature atherosclerosis and coronary heart disease.
Zimon, Magdalena, Pepperkok, Rainer, Bourbon, Mafalda, Graça, Rafael, Alves, Ana Catarina   +4 more
core   +1 more source

A functional classification of metropolitan communities [PDF]

Demography, 1973
Abstract Five major approaches to the functional classification of communities have been offered. Although most of them allow the recognition of a community as specialized in more than one function, their application necessitates consideration of the several individual functions one at a time.
openaire   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A functional-condition-based expert framework for safe participation in school physical education among children with health conditions

Translational Exercise Biomedicine
Regular physical activity is essential for healthy growth, cardiometabolic health, musculoskeletal development and psychosocial well-being in children and adolescents.
Rozenstoka Sandra, Atava-Cudare Endija, Bondins Jevgenijs, Kozlovska Liga, Silova Alla, Aispure Aiva, Dekmeijere-Trigubova Laila, Gobina Sarmite, Mickus Matiss, Savko Regina   +9 more
doaj   +1 more source

Relationship between functional capacity and socioeconomic status in a cohort of Turkish heart failure patients

Türk Kardiyoloji Derneği Arşivi, 2016
Objective: New York Heart Association (NYHA) classification predicts prognosis for heart failure (HF) patients. Socioeconomic status (SES) has the potential to affect treatment strategy and disease course.
Hakkı Kaya, Meltem Refiker Ege, Ali Zorlu, Osman Beton, Hasan Güngör, Ahmet Temizhan, Yeşim Güray, Yüksel Çavuşoğlu, Mehdi Zoghi, Mehmet Birhan Yılmaz, On Behalf Of TREAT-HF Investigators   +10 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Functional classification of unigenes.

, 2017
(A) COG (Clusters of Orthologous Groups) functional classification of unigenes; (B) KOG (Eukaryotic Ortholog Groups) functional classification of unigenes.
Chuankun Zhu (500656), Zhengjun Pan (3746665), Guoliang Chang (1575832), Hui Wang (30400), Nan Wu (200090), Huaiyu Ding (3746668)   +5 more
core   +1 more source

WebCARMA: a web application for the functional and taxonomic classification of unassembled metagenomic reads [PDF]

, 2009
Gerlach W, Jünemann S, Tille F, Goesmann A, Stoye J. WebCARMA: a web application for the functional and taxonomic classification of unassembled metagenomic reads. BMC Bioinformatics.
Jünemann, Sebastian, Stoye Jens, Sebastian Jünemann, Goesmann, Alexander ; https://orcid.org/, Goesmann Alexander, Tille Felix, Gerlach Wolfgang, Jens Stoye, Wolfgang Gerlach, Gerlach, Wolfgang, Stoye, Jens ; https://orcid.org/, Jünemann Sebastian, Tille, Felix, Felix Tille, Alexander Goesmann   +14 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source