Results 41 to 50 of about 253,481 (266)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Altered whole-brain resting-state functional connectivity and brain network topology in typhoon-related post-traumatic stress disorder

Therapeutic Advances in Psychopharmacology, 2023
Background: Altered resting-state functional connectivity has been found in patients with post-traumatic stress disorder (PTSD). However, the alteration of resting-state functional connectivity at whole-brain level in typhoon-traumatized individuals with
Hui Juan Chen, Jun Ke, Jie Qiu, Qiang Xu, Yuan Zhong, Guang Ming Lu, Yanglei Wu, Rongfeng Qi, Feng Chen   +8 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Age-Related Decline in the Variation of Dynamic Functional Connectivity: A Resting State Analysis

Frontiers in Aging Neuroscience, 2017
Normal aging is typically characterized by abnormal resting-state functional connectivity (FC), including decreasing connectivity within networks and increasing connectivity between networks, under the assumption that the FC over the scan time was ...
Yuanyuan Chen, Yuanyuan Chen, Weiwei Wang, Weiwei Wang, Xin Zhao, Xin Zhao, Miao Sha, Miao Sha, Ya’nan Liu, Ya’nan Liu, Xiong Zhang, Xiong Zhang, Jianguo Ma, Hongyan Ni, Dong Ming, Dong Ming   +15 more
doaj   +1 more source

Cognitive and clinical dysfunction, altered MEG resting-state networks and thalamic atrophy in multiple sclerosis. [PDF]

PLoS ONE, 2013
The relation between pathological findings and clinical and cognitive decline in Multiple Sclerosis remains unclear. Here, we tested the hypothesis that altered functional connectivity could provide a missing link between structural findings, such as ...
Prejaas Tewarie, Menno M Schoonheim, Cornelis J Stam, Marieke L van der Meer, Bob W van Dijk, Frederik Barkhof, Chris H Polman, Arjan Hillebrand   +7 more
doaj   +1 more source

Inferring functional connections between neurons [PDF]

Current Opinion in Neurobiology, 2008
A central question in neuroscience is how interactions between neurons give rise to behavior. In many electrophysiological experiments, the activity of a set of neurons is recorded while sensory stimuli or movement tasks are varied. Tools that aim to reveal underlying interactions between neurons from such data can be extremely useful.
Ian H, Stevenson, James M, Rebesco, Lee E, Miller, Konrad P, Körding   +3 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Quasi-periodic patterns of brain activity in individuals with attention-deficit/hyperactivity disorder

NeuroImage: Clinical, 2019
Individuals with attention-deficit/hyperactivity disorder have disrupted functional connectivity in the default mode and task positive networks. Traditional fMRI analysis techniques that focus on ‘static’ changes in functional connectivity have been ...
Anzar Abbas, Yasmine Bassil, Shella Keilholz   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Altered resting-state functional connectivity of the frontal-striatal reward system in social anxiety disorder.

PLoS ONE, 2015
We investigated differences in the intrinsic functional brain organization (functional connectivity) of the human reward system between healthy control participants and patients with social anxiety disorder.
Joshua Manning, Gretchen Reynolds, Zeynep M Saygin, Stefan G Hofmann, Mark Pollack, John D E Gabrieli, Susan Whitfield-Gabrieli   +6 more
doaj   +1 more source