Results 41 to 50 of about 270,621 (314)

Compositions of continuous functions and connected functions [PDF]

Proceedings of the American Mathematical Society, 1992
Suppose f : X → Y f:X \to Y is continuous and onto and g : Y → Z g:Y \to Z is such that g ∘ f : X → Z g \circ f:X \to Z has a property we are interested in. For which properties of
Kellum, Kenneth R., Rosen, Harvey
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Altered whole-brain resting-state functional connectivity and brain network topology in typhoon-related post-traumatic stress disorder

Therapeutic Advances in Psychopharmacology, 2023
Background: Altered resting-state functional connectivity has been found in patients with post-traumatic stress disorder (PTSD). However, the alteration of resting-state functional connectivity at whole-brain level in typhoon-traumatized individuals with
Hui Juan Chen, Jun Ke, Jie Qiu, Qiang Xu, Yuan Zhong, Guang Ming Lu, Yanglei Wu, Rongfeng Qi, Feng Chen   +8 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Quasi-periodic patterns of brain activity in individuals with attention-deficit/hyperactivity disorder

NeuroImage: Clinical, 2019
Individuals with attention-deficit/hyperactivity disorder have disrupted functional connectivity in the default mode and task positive networks. Traditional fMRI analysis techniques that focus on ‘static’ changes in functional connectivity have been ...
Anzar Abbas, Yasmine Bassil, Shella Keilholz   +2 more
doaj   +1 more source

Inferring functional connections between neurons [PDF]

Current Opinion in Neurobiology, 2008
A central question in neuroscience is how interactions between neurons give rise to behavior. In many electrophysiological experiments, the activity of a set of neurons is recorded while sensory stimuli or movement tasks are varied. Tools that aim to reveal underlying interactions between neurons from such data can be extremely useful.
Ian H, Stevenson, James M, Rebesco, Lee E, Miller, Konrad P, Körding   +3 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Altered resting-state functional connectivity of the frontal-striatal reward system in social anxiety disorder.

PLoS ONE, 2015
We investigated differences in the intrinsic functional brain organization (functional connectivity) of the human reward system between healthy control participants and patients with social anxiety disorder.
Joshua Manning, Gretchen Reynolds, Zeynep M Saygin, Stefan G Hofmann, Mark Pollack, John D E Gabrieli, Susan Whitfield-Gabrieli   +6 more
doaj   +1 more source

Age-Related Decline in the Variation of Dynamic Functional Connectivity: A Resting State Analysis

Frontiers in Aging Neuroscience, 2017
Normal aging is typically characterized by abnormal resting-state functional connectivity (FC), including decreasing connectivity within networks and increasing connectivity between networks, under the assumption that the FC over the scan time was ...
Yuanyuan Chen, Yuanyuan Chen, Weiwei Wang, Weiwei Wang, Xin Zhao, Xin Zhao, Miao Sha, Miao Sha, Ya’nan Liu, Ya’nan Liu, Xiong Zhang, Xiong Zhang, Jianguo Ma, Hongyan Ni, Dong Ming, Dong Ming   +15 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source