Results 81 to 90 of about 3,878,522 (308)

Convergent and divergent brain–cognition development in early adolescence

open access: yesNature Communications
How functional brain networks and cognition co-evolve during adolescent development remains poorly understood. Using baseline and Year 2 data from 2949 individuals in the Adolescent Brain Cognitive Development Study, we trained kernel ridge regression ...
Yapei Xie   +12 more
doaj   +1 more source

Altered resting-state functional connectivity of the frontal-striatal reward system in social anxiety disorder.

open access: yesPLoS ONE, 2015
We investigated differences in the intrinsic functional brain organization (functional connectivity) of the human reward system between healthy control participants and patients with social anxiety disorder.
Joshua Manning   +6 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Impact of autocorrelation on functional connectivity [PDF]

open access: yesNeuroImage, 2014
Although the impact of serial correlation (autocorrelation) in residuals of general linear models for fMRI time-series has been studied extensively, the effect of autocorrelation on functional connectivity studies has been largely neglected until recently.
Mohammad R. Arbabshirani   +10 more
openaire   +5 more sources

Whole-brain functional connectivity identification of functional dyspepsia.

open access: yesPLoS ONE, 2013
Recent neuroimaging studies have shown local brain aberrations in functional dyspepsia (FD) patients, yet little attention has been paid to the whole-brain resting-state functional network abnormalities.
Jiaofen Nan   +11 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

open access: yesFEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli   +2 more
wiley   +1 more source

Functional connectivity of insular efferences [PDF]

open access: yesHuman Brain Mapping, 2014
Abstract Objectives The aim of our study was to explore the functional connectivity between the insula and other cortical regions, in human, using cortico‐cortical evoked potentials (CCEPs) Experimental design We ...
Almashaikhi, Talal   +10 more
openaire   +3 more sources

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

open access: yesFEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt   +2 more
wiley   +1 more source

A reversal coarse-grained analysis with application to an altered functional circuit in depression [PDF]

open access: yes, 2013
Introduction: When studying brain function using functional magnetic resonance imaging (fMRI) data containing tens of thousands of voxels, a coarse-grained approach – dividing the whole brain into regions of interest – is applied frequently to ...
Shuixia Guo   +7 more
core   +1 more source

Long-range Auditory Functional Connectivity in Hearing Loss and Rehabilitation

open access: yes, 2021
Patients with age-related sensorineural hearing loss (HL) may benefit from auditory input amplification by using hearing aids (HA). However, the impact of both HL and HA-based rehabilitation on central auditory functional connectivity (FC) is not ...
Pellecchia, Maria Teresa   +10 more
core   +1 more source

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