Results 81 to 90 of about 6,363,686 (341)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Are current etiological theories of Alzheimer’s disease falsifiable? An epistemological assessment

Frontiers in Aging Neuroscience
Alzheimer’s disease (AD) research is plagued by a proliferation of competing etiological theories, often coexisting without undergoing systematic critical comparison. This article examines the epistemological limitations of the traditional falsifiability
Tommaso Costa, Tommaso Costa, Tommaso Costa, Donato Liloia, Donato Liloia   +4 more
doaj   +1 more source

Individual-specific functional connectivity of the amygdala: A substrate for precision psychiatry

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Disrupted functional connectivity of the amygdala may be central to mental illness. Yet, little is known about the functional connectivity of the amygdala in individuals, limiting our ability to understand and treat amygdala dysconnectivity ...
Chad M. Sylvester, Qiongru Yu, A. Srivastava, Scott A. Marek, Annie Zheng, D. Alexopoulos, Christopher D. Smyser, J. Shimony, M. Ortega, Donna Dierker, Gaurav H Patel, Steven M. Nelson, Adrian W. Gilmore, K. McDermott, Jeffrey J. Berg, Andrew T. Drysdale, Michael T. Perino, Abraham Z. Snyder, Ryan V. Raut, Timothy O. Laumann, Evan M Gordon, D. Barch, Cynthia E. Rogers, D. Greene, Marc Raichle, N. Dosenbach   +25 more
semanticscholar   +1 more source

Maintenance of cell type-specific connectivity and circuit function requires Tao kinase [PDF]

, 2019
Sensory circuits are typically established during early development, yet how circuit specificity and function are maintained during organismal growth has not been elucidated. To gain insight we quantitatively investigated synaptic growth and connectivity
González, Maria Sáez, Hu, Chun, Pedersen, Lisa Hedegaard, Petersen, Meike, Petruzzi, Mabel Matamala, Richter, Melanie, Sigrist, Stephan J., Spitzweck, Bettina, Tenedini, Federico Marcello, Wang, Denan   +9 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Altered Domain Functional Network Connectivity Strength and Randomness in Schizophrenia

Frontiers in Psychiatry, 2019
Functional connectivity is one of the most widely used tools for investigating brain changes due to schizophrenia. Previous studies have identified abnormal functional connectivity in schizophrenia patients at the resting state brain network level.
Victor M. Vergara, Victor M. Vergara, Victor M. Vergara, Eswar Damaraju, Jessica A. Turner, Jessica A. Turner, Godfrey Pearlson, Godfrey Pearlson, Aysenil Belger, Daniel H. Mathalon, Daniel H. Mathalon, Steven G. Potkin, Adrian Preda, Jatin G. Vaidya, Theo G. M. van Erp, Theo G. M. van Erp, Sarah McEwen, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun, Vince D. Calhoun   +21 more
doaj   +1 more source

Altered whole-brain resting-state functional connectivity and brain network topology in typhoon-related post-traumatic stress disorder

Therapeutic Advances in Psychopharmacology, 2023
Background: Altered resting-state functional connectivity has been found in patients with post-traumatic stress disorder (PTSD). However, the alteration of resting-state functional connectivity at whole-brain level in typhoon-traumatized individuals with
Hui Juan Chen, Jun Ke, Jie Qiu, Qiang Xu, Yuan Zhong, Guang Ming Lu, Yanglei Wu, Rongfeng Qi, Feng Chen   +8 more
doaj   +1 more source

Inferring functional connections between neurons [PDF]

Current Opinion in Neurobiology, 2008
A central question in neuroscience is how interactions between neurons give rise to behavior. In many electrophysiological experiments, the activity of a set of neurons is recorded while sensory stimuli or movement tasks are varied. Tools that aim to reveal underlying interactions between neurons from such data can be extremely useful.
Ian H, Stevenson, James M, Rebesco, Lee E, Miller, Konrad P, Körding   +3 more
openaire   +2 more sources

Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson’s disease:A task-based fMRI study [PDF]

, 2015
Background: The neural substrates of visual hallucinations remain an enigma, due primarily to the difficulties associated with directly interrogating the brain during hallucinatory episodes.
Halliday, Glenda M., Hornberger, Michael, Lewis, Simon J. G., Muller, Alana J., O’Callaghan, Claire, Shine, James M.   +5 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source