Results 211 to 220 of about 4,566,680 (308)

Bexicaserin for the treatment of seizures in developmental and epileptic encephalopathies: A phase 1b/2a trial (PACIFIC)

Epilepsia, EarlyView.
Abstract Objective This randomized, double‐blind, phase 1b/2a clinical trial was designed to evaluate the safety, tolerability, and efficacy of oral bexicaserin versus placebo for the treatment of seizures in adolescents and adults with developmental and epileptic encephalopathies (DEEs).
Dennis J. Dlugos, Ingrid E. Scheffer, Jacqueline A. French, David G. Vossler, Chad Orevillo, Shikha Polega, Randall Kaye, and the LP352‐201 Study Investigators, Kore Liow, Ena Zhu, Jennifer Waldron, Hayley Groubert, Alexis Anderson, Pavel Klein, Salman Hashmi, Shicong Ye, Anita Farhi, David Vossler, Dione M. Froman, Shannon L. Hoffman‐Huffaker, Ki Hyeong Lee, AnnaLyn Dallas, Amir Arain, Laura Beeler, Michael Macken, Irena Bellinski, Elizabeth Cunningham, James Renfroe, Shezsay Colbert, Robert Hogan, Patty Schaefer, Susan Shaw, Sheetal Desai, Ahmed Sadek, Haile Robertson, Kamil Detyniecki, Anabela Cieslicki, Ruben Kuzniecky, Sarah Goodman, Selim Benbadis, Marina Azevedo, Sami Aboumatar, Julie Biel, Nilika Singhal, Emerald Wan, Evan Fertig, Hannah Hart, Debopam Samanta, Sarah Hankins, Steven Wolf, Patricia Pena, Robert Nahouraii, M. J. Mari, David Burdette, Stephanie Mueller, Karen Keough, Victoria Henderson, Talitha Durgin, Terence O’Brien, Rafael Smith, Jack Germaine, Kate Riney, Lori Anthony, David Reutens, Kimberley Irwin, Michael Fahey, Melissa Batt, Stephanie Kaladis, Kasthoori Jeyachanthiran, Ingrid Scheffer, Rebecca Wharrie, Greesha Zacharia, Brittany Walsh, Heather Robinson, Sharon Ganter   +74 more
wiley   +1 more source

Gut jet lag: how circadian rhythm disruption undermines the Chrono-Microbiota-Motility axis and induces functional constipation. [PDF]

Front Nutr
Li J, Yu K, Sui X, Deng H, Leng Y, Liu T.   +5 more
europepmc   +1 more source

Clinical Observation on Functional Constipation and Regulation of Serum SP and VIP by Exploring the “Brain-Intestinal Axis” of Shu-Mu Combination [PDF]

星儒 任
openalex   +1 more source

‘BJUI Clinical Dilemma’: the overactive bladder

BJU International, EarlyView.
Oliver Gross, Marcio A. Averbeck, Stefania Musco, Véronique Phé, Desiree Vrijens, Blayne Welk, Glenn T. Werneburg, Thomas M. Kessler   +7 more
wiley   +1 more source

Comprehensive assessment of erenumab efficacy in participants with high‐frequency episodic migraine with at least one previously failed preventive treatment: The EMBRACE study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To evaluate the effect of erenumab treatment beyond monthly migraine days in patients with high‐frequency episodic migraine who did not respond to at least one previous migraine preventive treatment. Background Reduction in monthly migraine days has been the efficacy standard for migraine preventive treatments; however, it does not ...
Gabriel Paiva da Silva Lima, Renata Rao, Gyöngyi Szabó, Sebastian Szklener, Cristina Tassorelli, Marcin Nastaj, Denise E. Chou, Ani C. Khodavirdi, Mahan Chehrenama, Yineng Zhu, Ajay K. Bhatia, David W. Dodick   +11 more
wiley   +1 more source

Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites. [PDF]

Front Nutr
Xiao P, Song T, Li XL, Xiao YM, Wang RX, Song FF, Li D, Zhang AH, Wang Y, Zhang T.   +9 more
europepmc   +1 more source

FUNCTIONAL CONSTIPATION, DYNAMICS OF PRESENTATIONS, DIAGNOSTICS, INDIVIDUAL APPROACHES TO THE TREATMENT

, 2017
O. N. Minushkin
openalex   +2 more sources

Gepants for headache prevention in children and adolescents: A multicenter chart review study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Introduction There is an unmet need for safe, evidence‐based pharmacologic treatments for migraine prevention in children and adolescents. Rimegepant and atogepant, calcitonin gene‐related peptide receptor antagonists (gepants), have been shown to be efficacious and well‐tolerated preventive treatments in adults with migraine.
Lauren Shin, Olivia Mentz, Amy A. Gelfand, Blanca Marquez de Prado, Hannah Shapiro, Ann Oh, Ogo‐Oluwa Onifade, Jessica Saunders, Nichelle Raj, Christina L. Szperka   +9 more
wiley   +1 more source

Anorectal manometric data depend on the direction of pressure measurements in healthy individuals and in patients with functional constipation. [PDF]

Ann Coloproctol
Yao H, Bao S, Sun D, Huang Z, Yang M, Gregersen H.   +5 more
europepmc   +1 more source

Cytokine biomarkers and their relationship to symptoms and quality of life in people with HIV‐associated Kaposi sarcoma

HIV Medicine, EarlyView.
Abstract Introduction Quality of life (QOL) is an essential component of care in people with HIV‐associated Kaposi sarcoma (HIV‐KS). Kaposi sarcoma herpes virus (KSHV) promotes cytokine expression and a dysfunctional inflammatory environment, contributing to KS pathogenesis and progression.
Fahmida Shaik, Thomas Smith Uldrick, Mikateko Mazinu, Nomonde Gwebushe, Anisa Mosam   +4 more
wiley   +1 more source