Results 281 to 290 of about 110,424 (352)

Length of the Adult Human Colon in Health and Constipation Measured Using Magnetic Resonance Imaging

open access: yesNeurogastroenterology &Motility, EarlyView.
Colon length was measured in adult healthy volunteers, people with chronic constipation, and people with IBS with constipation using MRI. Colon length is significantly longer in chronic constipation. The chronically constipated colon is unable to accommodate longitudinally in response to fluid influx from a macrogol challenge.
Faiz Alqarni   +16 more
wiley   +1 more source

Effect of Linaclotide on Colonic Motility Assessed With Intraluminal Colonic High‐Resolution Manometry in Healthy Subjects. An Acute, Open Label, Randomized, Crossover, Reader‐Blinded Study

open access: yesNeurogastroenterology &Motility, EarlyView.
Our study showed that, in healthy controls, acute administration of linaclotide increased the total number of long‐distance propagating and the pre‐prandial pancolonic pressurizations. Further studies need to address whether the observed effects are directly or indirectly mediated by the mechanism of action of this useful medication to treat chronic ...
Christian Lambiase   +7 more
wiley   +1 more source

Development and Testing of an Owner‐Reported Outcome Measure of Clinical Signs and Quality of Life in Dogs Treated With Chemotherapy

open access: yesVeterinary and Comparative Oncology, EarlyView.
ABSTRACT Cancer is a leading cause of mortality in older dogs. Despite the prevalence of chemotherapy in canine oncology, a good understanding of owners' observations of side effects and clinical signs in real time is still lacking. Owners' perceptions and reporting of clinical signs play an important role in monitoring a dog's condition during ...
Jenny Harris   +5 more
wiley   +1 more source

Do Most Children with Functional Constipation Meet the Commonly Used Clinical Trial Endpoints? [PDF]

open access: yesChildren (Basel)
Arrizabalo S   +4 more
europepmc   +1 more source

Altered peripheral CRY1 gene expression may contribute to both organic and functional gastrointestinal disease

open access: yesExperimental Physiology, EarlyView.
ABSTRACT Gastrointestinal conditions such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) are characterized by alterations in physiological and immune functions. Given the circadian clock influences gastrointestinal physiology and immunity, we hypothesized that the peripheral circadian clock is altered in these patients and ...
Sophie Fowler   +12 more
wiley   +1 more source

High Score of ELST‐Blue in Endoscopic Ultrasonography Strain Elastography May Provide a High Risk Group of Early Chronic Pancreatitis with the Reduction of Apolipoprotein A2‐i Index

open access: yesDEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Background To evaluate the usefulness of the ELST‐blue score to explore its potential application in identifying high‐risk groups for early chronic pancreatitis (ECP) through reflecting on pancreatic elasticity and the reduction of pancreatic function, and we tried to demonstrate whether the ELST‐blue score was significantly associated with ...
Ken Nakamura   +17 more
wiley   +1 more source

Home - About - Disclaimer - Privacy