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Linaclotide (Linzess) for Functional Constipation

The Medical Letter on Drugs and Therapeutics, 2023
The guanylate cyclase-C receptor agonist linaclotide (Linzess – Abbvie/Ironwood) was first approved by the FDA in 2012 for treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation in adults.
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Age of Onset of Functional Constipation

Journal of Pediatric Gastroenterology and Nutrition, 2016
ABSTRACTIn a review of 538 children with functional constipation, we analyzed ages of presentation and onset, symptom duration, and behavioral/developmental problems. We divided the subjects into quartiles (Q1–Q4) based on age of onset. Median onset age was 2.3 years. The oldest group had the shortest symptom duration before referral at 1.8 ± 1.8 years
Stanton, Malowitz   +4 more
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Management of functional constipation in childhood

British Journal of Community Nursing, 2003
Functional constipation is a common childhood condition. In the majority of cases the constipation develops as a result of a complex weave of factors including specific triggers, e.g. reduced fluid intake following a viral infection or periods of restricted access to the toilet.
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FUNCTIONAL CONSTIPATION IN CHILDREN

Journal of Urology, 2004
ABSTRACT Purpose: Constipation in children increases the likelihood of urinary incontinence, bladder overactivity, dyscoordinated voiding, a large capacity, poorly emptying bladder, recurrent urinary tract infection and deterioration of vesicoureteral reflux.
J.W. CHASE   +4 more
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Functional Constipation and Obstructed Defecation

Surgical Clinics of North America
Constipation encompasses symptoms of decreased colonic motility or difficulty with the defecation process. As a broad definition, this can be inclusive of functional constipation (FC) or colonic inertia, obstructed defecation (OD), and irritable bowel syndrome-constipation type (IBS-CS). After excluding IBS-C, FC and OD diagnosis and management require
Mary T, O'Donnell, Sarah M, Haviland
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Oral Prucalopride in Children With Functional Constipation

Journal of Pediatric Gastroenterology and Nutrition, 2013
ABSTRACTBackground and Objectives:Prucalopride is a selective, high‐affinity 5‐HT4 receptor agonist with gastrointestinal prokinetic activities. The aim of this study was to evaluate the pharmacokinetics, efficacy, safety, and tolerability of prucalopride oral solution in children, ages 4 years or older to 12 years or younger, with functional ...
Winter, Harland S.   +8 more
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Functional Constipation and Cow's‐Milk Allergy

Journal of Pediatric Gastroenterology and Nutrition, 2014
N ...
Miceli Sopo S., Arena R., Scala G.
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Functional constipation.

Seminars in pediatric surgery, 1995
Constipation is a common problem in children. Most patients have functional constipation, with or without soiling. The treatment program for functional constipation includes various forms of behavioral therapy and psychological approaches, and consists of education, disimpaction, prevention of reaccumulation of stools with fiber and laxatives, and ...
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Functional constipation in childhood

Nurse Prescribing, 2011
Although idiopathic constipation is one of the commonest problems in childhood, it is often the most poorly managed.Left untreated, constipation can become chronic and result in devastating problems, including soiling, as well as pain and distress for the child and family.
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Editorial: IBS With Constipation, Functional Constipation, Painful and Non-Painful Constipation: e Pluribus…Plures?

American Journal of Gastroenterology, 2014
IBS with constipation (IBS-C) and chronic constipation (CC) can be difficult to distinguish clinically. The Rome III criteria create mutual exclusion between IBS-C and CC, based on the presence of abdominal pain, which is a defining criterion for IBS-C. Previous surveys found that up to 45% of CC patients have abdominal pain and other IBS features.
Filippo, Cremonini, Anthony, Lembo
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