Results 161 to 170 of about 29,887,370 (259)

Clustering for multivariate functional data

, 2016
A novel multivariate k-centers functional clustering algorithm for the multivariate functional data is proposed. We assume that clusters can be defined via the functional principal components subspace projection for each variable.
Li, Pai-Ling;Kuo, Ling-Cheng
core  

Functional data analysis of college students' sleep patterns and their relationships with academic performance and social networks: A four-year longitudinal study. [PDF]

PLoS One
Zhao Y, Zhou H.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Functional Data Analysis-Based Framework for Modeling and Multi-Objective Optimization of Sustained-Release Drug Delivery Systems. [PDF]

Pharmaceutics
Ren H, Han M, Qiao Y, Cui Y, Hao C, Lou Y, Jing G, Liu Q, Yang L, Zheng L, Qiu L.   +10 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Curve Data Classification via Functional Regression Analysis

, 2012
計畫編號：NSC100-2118-M032-006研究期間：20110801~20120731研究經費：315,000本計畫將討論曲線資料(curve data)的分類(classification)問題，尤其是當存 在有與分類相關的解釋變數(covariates)時，探討如何將這些解釋變數有用之訊 息有效加入函數型分類方法中。我們將曲線資料視為隨機過程的實際觀測值， 並假設在多個已知分類下，各類隨機函數的平均函數與共變異函數均可能相 異。在給定相關解釋變數的訊息下，我們將利用條件函數型主成份分析 ...
李百靈
core  

Functional Data Strengthen Clinical Validation of PhenoScore Phenotype-Guided AI for ANKRD11 Missense Variants. [PDF]

Clin Genet
Andriessen E, de Boer E, Lyon GJ, de Vries BBA, Ockeloen CW, Dingemans AJM.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Parallel multilink group joint ICA (pmg-jICA): Fusion of 3D structural and 4D functional data across multiple resting fMRI networks. [PDF]

Netw Neurosci
Khalilullah KMI, Phadikar S, Agcaoglu O, Sui J, Duda M, Adali T, Calhoun VD.   +6 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source