Results 61 to 70 of about 3,667,449 (266)

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Trend filtering for functional data

Stat, 2023
Despite increasing accessibility to function data, effective methods for flexibly estimating underlying functional trend are still scarce. We thereby develop a functional version of trend filtering for estimating trend of functional data indexed by time or on general graph by extending the conventional trend filtering, a powerful nonparametric trend ...
Tomoya Wakayama, Shonosuke Sugasawa
openaire   +2 more sources

Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip

Advanced Science, 2020
A functional, human, multiorgan, pumpless, immune system‐on‐a‐chip featuring recirculating THP‐1 immune cells with cardiomyocytes, skeletal muscle, and liver in separate compartments in a serum‐free medium is developed. This in vitro platform can emulate
Trevor Sasserath, John W. Rumsey, Christopher W. McAleer, Lee Richard Bridges, Christopher J. Long, Daniel Elbrecht, Franz Schuler, Adrian Roth, Christina Bertinetti‐LaPatki, Michael L. Shuler, James J. Hickman   +10 more
doaj   +1 more source

An Adaptive-to-Model Test for Parametric Functional Single-Index Model

Mathematics, 2023
Model checking methods based on non-parametric estimation are widely used because of their tractable limiting null distributions and being sensitive to high-frequency oscillation alternative models.
Lili Xia, Tingyu Lai, Zhongzhan Zhang
doaj   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Functional Data Analysis of Dynamic PET Data [PDF]

Journal of the American Statistical Association, 2018
One application of positron emission tomography (PET), a nuclear imaging technique, in neuroscience involves in vivo estimation of the density of various proteins (often, neuroreceptors) in the brain. PET scanning begins with the injection of a radiolabeled tracer that binds preferentially to the target protein; tracer molecules are then continuously ...
Yakuan Chen, Jeff Goldsmith, R. Todd Ogden   +2 more
openaire   +2 more sources

The ability of SABRE, a new quantitative receptor function model, to quantify receptor binding from even challenging concentration-effect data with a single unified fit

Frontiers in Pharmacology
The Signal Amplification, Binding affinity, and Receptor-activation Efficacy (SABRE) model is the most recent general and quantitative model of receptor function.
Barbara Olah, Barbara Olah, Vera Tarjanyi, Gabor Viczjan, Ignac Ovari, Andras Csoto, Zoltan Szilvassy, Bela Juhasz, Judit Zsuga, Rudolf Gesztelyi, Tamas Erdei   +10 more
doaj   +1 more source

Psychosocial Functioning After Pediatric Bone Sarcoma: Generic and Survivor‐Specific Outcomes in Adolescent and Young Adult Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric bone sarcoma patients and survivors may experience psychosocial challenges related to childhood cancer after their intensive, body‐altering treatment. This cross‐sectional study aimed to evaluate generic and survivor‐specific psychosocial outcomes in a national cohort of pediatric bone sarcoma patients and survivors, and ...
Hinke van der Hoek, Heleen Maurice‐Stam, Laura R. Beek, Jennifer van Dijk, Marjolein E. M. Langemeijer, Relinde W. Slooff‐Lentink, Alied M. van der Aa‐van Delden, Anne Westerweel, Marloes van Gorp, Hendrik W. B. Schreuder, Lianne M. Haveman, W. Peter Bekkering, Leonie G. Tigelaar, Johannes H. M. Merks, Martha A. Grootenhuis   +14 more
wiley   +1 more source

Modelling the Impact of Community Well-Being on Individual Well-Being. An Empirical Appraisal of Alternative Approaches

Journal of Modern Science
Objectives Measuring complex multidimensional phenomena such as the community well-being over time provides several challenges. The main difficulties are due to changes of well-being – at both group/community level and at the individual/household level.
Włodzimierz Okrasa
doaj   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla, Sean Carter, Andrew Wood, Sandra Staffieri, Andrew Dodgshun, David D. Eisenstat, Michael Sullivan   +6 more
wiley   +1 more source