Results 211 to 220 of about 3,232,072 (306)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Functional data analysis-based yield modeling in year-round crop cultivation. [PDF]

Hortic Res
Matsui H, Mochida K.
europepmc   +1 more source

Learning the properties of adaptive regions with functional data analysis. [PDF]

PLoS Genet, 2020
Mughal MR, Koch H, Huang J, Chiaromonte F, DeGiorgio M.   +4 more
europepmc   +1 more source

Methods and Applications of Multivariate Pattern Analysis in Functional MRI Data Analysis.

, 2015
Yash Shah
openalex   +1 more source

EEG-EyeTrack: A Benchmark for Time Series and Functional Data Analysis with Open Challenges and Baselines [PDF]

Tiago Afonso, Florian Heinrichs
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Comparing Social Media Communities using Functional Data Analysis. [PDF]

Proc Annu Hawaii Int Conf Syst Sci
Champon X, Jasser J, Jayalath C, Garibay I, Rand W, Garibay O.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Functional data analysis and prediction tools for continuous glucose-monitoring studies. [PDF]

J Clin Transl Sci, 2020
Gecili E, Huang R, Khoury JC, King E, Altaye M, Bowers K, Szczesniak RD.   +6 more
europepmc   +1 more source

Data driven analysis of brain activity and functional connectivity in fMRI

, 2003
Silke Dodel
openalex   +1 more source